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IL1B — IL2

Text-mined interactions from Literome

Siese et al., Scand J Immunol 1999 (Thymoma) : Using specific enzyme inhibitors of protein kinases ( PK ) C and A, mitogen activated protein kinase ( MAPK ), phospholipase A2 (PLA2), phosphatidylinositol dependent ( PI ) -PLC and PC-PLC, we showed that IL-1beta induced IL-2 synthesis was dependent on all investigated kinases and phospholipases, except PC-PLC
Leseth et al., Neuroreport 1999 : However, after 1 day of organ culture, fully defined concentration-response curves were obtained in artery segments exposed to sarafotoxin S6c. Organ culture in the presence of either interleukin-1 beta or tumour necrosis factor-alpha, but not interleukin-2 or interleukin-6, further amplified the maximal contraction to sarafotoxin S6c
Berendji et al., Mol Med 1999 : NO inhibits IL-1beta induced IL-2 mRNA expression in EL4-6.1 cells
Ribbens et al., Immunology 2000 : Under these conditions IL-1beta production was induced almost exclusively by Th1 cells and was dependent on the presence and dose of IL-2 or IL-15, and on cell-cell contact, as demonstrated by double-chamber cultures ... Preferential expression on Th1 cells of CD11b correlated with their capacity to induce IL-1beta production by THP-1 cells in the presence of IL-2 or IL-15, but anti-CD11b monoclonal antibody could not inhibit this activity
Bosco et al., J Immunol 2000 (Inflammation) : Furthermore, HA markedly suppressed the ability of IL-2 to induce IL-1 beta , TNF-alpha, IL-6, and IL-8 mRNA expression and protein secretion by monocytes
de Haan et al., Transplantation 2000 : In this assay also the effects of anti-CD28 antibody and interleukin- (IL) 1beta , IL-6, or IL-12 mediated costimulation on responder T cell proliferation and IL-2 production were investigated ... IL-1beta enhanced IL-2 production and proliferation of allostimulated resting T cells but its presence was not essential
Kelley et al., Lipids 2001 : CLA supplementation did not alter the in vitro secretion of prostaglandin E2, leukotriene B4, interleukin-1beta (IL-1beta) , or tumor necrosis factor alpha (TNFalpha) by PBMC simulated with lipopolysaccharide, and the secretion of IL-2 by PBMC stimulated with phytohemagglutinin
Lottaz et al., J Invest Dermatol 2001 : In interleukin-1beta transfected human dermal fibroblasts, interleukin-8 was induced through an autocrine activity of interleukin-1beta
Xia et al., Zhonghua Wai Ke Za Zhi 2001 (Acute Disease) : The expression of IL-1 beta , IL-4, IL-10, IFN gamma was up-regulated, and the expression of IL-2 , CD25, IL-5, IL-6, TNF alpha was significantly inhibited in group A
Rodriguez-Juan et al., Tissue Cell 2001 : Cell surface phenotype and cytokine secretion in Caco-2 cell cultures : increased RANTES production and IL-2 transcription upon stimulation with IL-1beta ... Cytokine analysis showed an increased RANTES synthesis and IL-2 transcription upon stimulation with IL-1beta
Kovár et al., Parasitol Res 2002 : ELISA ( protein level ) and RNAse protection assay ( mRNA level ) showed that SGE enhanced interleukin (IL)-1alpha, IL-1beta , IL-1Ra, IL-6, and IL-12p40 cytokines, whereas production of IL-2 , IL-5, IL-10, and IL-13 was decreased
Augstein et al., Biochem Biophys Res Commun 2003 (Diabetes Mellitus, Type 1) : To investigate whether TGZ acts by affecting the ICAM-1/LFA-1 pathway and/or the Th1/Th2 cytokine balance in NOD mice, we analysed the IL-1beta induced ICAM-1 expression on islet-cells and the LFA-1, CD25, IL-2 , IFN-gamma, IL-4, and IL-10 expression on splenocytes
Hassanain et al., Neuroscience 2003 : In particular, interleukin-1beta in the medial hypothalamus potentiates defensive rage behavior elicited from the periaqueductal gray in the cat, and the potentiating effects of interleukin-1beta on this form of emotional behavior are mediated via a 5-HT2 receptor mechanism
Fujiwara et al., Cancer Res 1992 : Specific inhibition of interleukin 1 beta gene expression by an antisense oligonucleotide : obligatory role of interleukin 1 in the generation of lymphokine activated killer cells
Conti et al., Int J Immunopharmacol 1992 (Leukemia, T-Cell) : The pretreatment of human peripheral blood mononuclear cells ( PBMC ) with hrIL-1ra ( 0.25-250 ng/ml ) inhibits IL-1 alpha or IL-1 beta and enhances, in a dose dependent manner, the stimulatory effect of IL-2 on their natural killer ( NK ) activity against a lymphoid cell line MOLT-4
Peters et al., Immunology 2003 : Mitogen stimulation of embryonic day 18 and day 1 post-hatch thymocytes induced up-regulation of IFN-gamma, IL-1beta and TGF-beta transcripts, and down-regulation of IFN-alpha, IFN-beta and IL-2 transcripts, with a higher induction of IFN-gamma, IL-1beta and TGF-beta transcripts in more immature T-cell-receptor negative ( TCR- ) than TCR+ ( TCR1+, TCR2+, or TCR3+ ) subsets
Chechlińska et al., Cell Mol Biol Lett 2004 (Adenocarcinoma...) : We have shown that the sera of lung cancer patients affect the response of ConA stimulated normal peripheral blood mononuclear cells by decreasing the expression of IL-2Ralpha and inhibiting the release of IL-1beta and IL-2
Soboslay et al., Clin Exp Immunol 1992 (Dermatitis...) : Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta , tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of IL-1 beta, IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Hornyak et al., Vascul Pharmacol 2005 (Capillary Leak Syndrome...) : Serum levels of IL-1beta , IL-4 and IL-12 were not measurably induced by IL-2 treatment
Altomonte et al., Clin Rheumatol 1992 (Arthritis, Rheumatoid) : Further IL-1b and TNF-a were significantly elevated in RA patients with active disease and IL-2 was significantly reduced when compared with patients with low active disease
Luz et al., Neuropeptides 2006 (Dehydration...) : These results suggest that the central activation of interleukin-1 receptors by IL-1beta is able to impair the thirst inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2 , TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Bernardino et al., J Neurochem 2008 (Encephalitis...) : Potentiation of AMPA toxicity was prevented when IL-1beta production or its receptor signaling were blocked by an inhibitor of interleukin-converting-enzyme or IL-1 receptor antagonist during application of LPS + ATP
Haber et al., Exp Parasitol 2009 (Hyperalgesia...) : Leishmania major : interleukin-13 increases the infection induced hyperalgesia and the levels of interleukin-1beta and interleukin-12 in rats
Gruenbacher et al., Blood 2009 : Stimulation of CD56+ cells containing both DCs and abundant gammadelta T cells with zoledronate and interleukin-2 (IL-2) resulted in the rapid expansion of gammadelta T cells as well as in IFN-gamma, TNF-alpha, and IL-1beta but not in IL-4, IL-10, or IL-17 production
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1 , tumor necrosis factor, and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Kasai et al., Horm Metab Res 1990 : TSH, IL-2 and other peptide hormones did not inhibit the binding of 125I-IL-1 beta to thyroid cells
Bienkowski et al., J Biol Chem 1990 : Culture medium conditioned by phorbol 12-myristate 13-acetate differentiated THP-1 cells contained interleukin 1 (IL-1) antagonist activity as measured by inhibition of both IL-1 beta binding to receptors on YT cells and inhibition of IL-1/phytohemagglutinin stimulated IL-2 synthesis by LBRM-33-1A5 T cells
Numerof et al., Cell Immunol 1990 : Pro-interleukin-1 beta production by a subpopulation of human T cells, but not NK cells, in response to interleukin-2 ... We examined cytokine production by IL-2 treated, nonmonocytic PBMC and found that a population of nonadherent low-density cells ( NLDC ) produced both IL-1 beta and TNF alpha in response to IL-2
Galli et al., Cell Immunol 1990 : Herein we present evidence that this subset of lymphocytes can synthesize IL-1 beta mRNA constitutively and that the cytoplasmic mRNA levels of IL-1 beta can be increased rapidly by interleukin (IL)-2 ... In addition, MAb to the p75 IL-2 receptor on LGL abrogated IL-2 induction of IL-1 beta mRNA, suggesting that IL-2 signaling via the p75 IL-2 receptor induced IL-1 beta gene expression in LGL
Rodriguez-Cimadevilla et al., Blood 1990 (Leukemia, Myeloid, Acute) : Coordinate secretion of interleukin-1 beta and granulocyte-macrophage colony stimulating factor by the blast cells of acute myeloblastic leukemia : role of interleukin-1 as an endogenous inducer
Espevik et al., Cell Immunol 1990 : The effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Mier et al., J Immunol 1987 (Liver Neoplasms, Experimental) : These results indicate that the indirect effect of IL 2 on hepatic acute phase protein synthesis is mediated by IL 1-beta
Lee et al., J Immunol 1987 : The effect of human recombinant tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) on interleukin 2 receptor (IL-2R) expression on YT cells was examined
Herrmann et al., J Immunol 1989 : Induction of IL-1 beta secretion by IFN gamma and IL-2
Quill et al., J Immunol 1989 : This response to IL-1 plus IL-2 could be induced by IL-1 alpha or IL-1 beta and by membrane bound IL-1 on macrophages
Kovacs et al., J Immunol 1989 (Second Messenger Systems) : IL-2 induction of IL-1 beta mRNA expression in monocytes ... In contrast, IL-2 induction of IL-1 beta mRNA expression is blocked only by 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine, suggesting that PKc, and not CaM kinase, is activated by IL-2
Hackett et al., J Immunol 1988 : Whereas TNF-alpha had little effect, IL-1 beta augmented IL-2 mRNA expression and IL-2 production by mitogen stimulated cells
Numerof et al., J Immunol 1988 : IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells ... In addition, Leu M3+ monocytes obtained through FACS, but not CD16+ NK cells, produced both IL-1 alpha and IL-1 beta in response to IL-2
Mauviel et al., Biochem Biophys Res Commun 1988 : The ability of the two forms of interleukin-1 , IL-1 alpha and IL-1 beta, to induce IL-1 beta gene expression in human skin fibroblasts was studied in vitro, using Northern blot hybridization
Kita et al., C R Seances Soc Biol Fil 1993 (Disease Models, Animal...) : After HSV-1 infection, IFN-alpha, IFN-beta, IFN-gamma, IL-1 beta , IL-4, IL-6 and TNF-alpha mRNA were significantly induced, but IL-2 , IL-3 and IL-5 mRNA were not induced
Kita et al., C R Seances Soc Biol Fil 1994 : Although the expressions of IL-1 beta , IL-4, IL-5, IL-6, TNF-alpha and IFN-gamma mRNA were detected in all the embryos tested, the expressions of IL-2 , IL-3, IFN-alpha and IFN-beta mRNA were not detected at all
Matsubara et al., No To Shinkei 1995 (Myasthenia Gravis) : Immediately after PP, PBM IL-2 production decreased and PBM IL-1 beta production increased
Baxevanis et al., Immunopharmacol Immunotoxicol 1994 : The requirement for IL-1 beta and TNF-alpha in both IL-2 production and generation of suppressor activity was shown by three different approaches which included ( a ) blocking of HLA-DR molecules on monocytes which prevented monokine consumption during the early stages of culture, ( b ) blocking of HLA-A, B,C molecules on monocytes which prevented monokine consumption and IL-2 production late in culture, and ( c ) neutralization of monokine activity late in culture which resulted in highly reduced IL-2 production
Wallays et al., Eur Cytokine Netw 1993 : In the presence of PWM-RBC ( but not of soluble PWM ), T cell proliferation and IL-2 production could strongly and consistently be enhanced by recombinant IL-1 beta and IL-6
Panzer et al., Clin Exp Immunol 1993 : We show in this system that exogenously added IL-1 beta , IL-6 and TNF-alpha induces IL-2 receptor (R) up-regulation and IL-2 production, and proliferation by both CD4+ and CD8+ cells
Heaton et al., Cancer Res 1993 : These data suggest the interaction of IL-2 and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is required for maximal secretion of IL-1 beta , TNF-alpha, TNF-beta, and IFN-gamma
Yoza et al., J Biol Chem 1996 : In human monocytes, interleukin 1beta protein production and steady state mRNA levels are increased in response to lipopolysaccharide, predominantly as a result of increased transcription of the interleukin 1beta gene
Yamaoka et al., Scand J Gastroenterol 1995 (Gastritis...) : Although IL-1 beta and IFN-gamma mRNA were detected in most specimens, IL-2 , IL-3, IL-4, IL-5, IL-9, TNF-alpha, and IFN-beta mRNA were not detected at all
Kang et al., Spine (Phila Pa 1976) 1997 (Intervertebral Disc Displacement) : Normal and herniated human intervertebral disc specimens were cultured to study the effects of interleukin-1 beta on the production of nitric oxide, interleukin-6 , prostaglandin E2, and matrix metalloproteinases ... Normal, control disc specimens significantly increased their production of matrix metalloproteinases, nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta ... Herniated lumbar and cervical discs, which were spontaneously releasing increased levels of these biochemical agents, further increased their production of nitric oxide, interleukin-6 , and prostaglandin E2 in response to interleukin-1 beta
Kiriyama et al., J Neuroimmunol 1997 (Glioblastoma) : In human glioblastoma A172 cells, interleukin-6 (IL-6) production was induced by interleukin-1 beta (IL-1 beta) and dibutyryl cyclic AMP
Bosco et al., J Immunol 1997 : Furthermore, anti-CD14 mAbs effectively inhibited the secretion of IL-8 and IL-1beta in response to IL-2 ... Expression of IL-1beta was also augmented by IL-2 in U937/CD14 cells
Appel et al., Neuroreport 1997 (Inflammation) : Interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma) induced similar effects on GDNF production, whereas IL-2 and IL-6 had no significant effects
Berghella et al., Cancer Immunol Immunother 1998 (Colorectal Neoplasms) : To address these questions at the immunological level in a group of patients and healthy subjects, we determined the sIL-2R level in the serum and its release from peripheral blood mononuclear cells ( PBMC ) as a function of tumour necrosis factor (TNF) alpha, IL-1 alpha, IL-1 beta , IL-2, interferon (IFN) gamma, IL-4, IL-6 and IL-10 levels in the serum and PBMC production ; and PBMC proliferative responses to IL-2 , IL-4 and anti-CD3 monoclonal antibody ( CD3 ), variously combined
McDermott et al., Clin Cancer Res 1998 (Carcinoma, Renal Cell...) : Whole-blood functional assays indicated that sufficient s ( CHO ) IL-1R was present in the circulation at top dose levels to inhibit the in vitro effects of IL-1beta on IL-8 induction ; however, no effect on IL-2 induced IL-8 induction, or on the IL-1beta- or IL-2 induced tumor necrosis factor production, was observed
Macciò et al., Gynecol Oncol 1998 (Ovarian Neoplasms) : The serum levels of interleukin-(IL-)1 alpha, IL-1 beta , IL-2, IL-6, TNF alpha, and sIL-2R and the proliferative response of peripheral blood mononuclear cells ( PBMC ) to phytohemagglutinin ( PHA ), anti-CD3 monoclonal antibody ( mAb ), recombinant IL-2 ( rIL-2 ), and the combination of PHA or anti-CD3 mAb with rIL-2 were studied and correlated with serum levels of C-reactive protein (CRP) in women with advanced epithelial ovarian cancer
García de Galdeano et al., Eur Cytokine Netw 1998 (Melanoma, Experimental) : Finally, we tested the effect of IL-1beta , IL-6 and IL-2 on the expression of the IL-2 receptor (IL-2R)
Aihara et al., Dig Dis Sci 1998 : Live H. pylori induced production of many cytokines, such as IL-1beta , IL-10, IL-8, IFN-gamma, and TNF-alpha, whereas we could not detect IL-2 or IL-4
Plata-Salamán et al., Am J Physiol 1998 (Fever...) : The results show that 1 ) both IL-1beta and IL-6 induce fevers in obese and lean rats ; 2 ) IL-1beta induces a significantly higher fever response in obese rats than it does in lean rats ; 3 ) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats ; 4 ) IL-2 induces a moderate fever response in lean but not obese rats ; 5 ) TNF-alpha induces a similar fever response in obese and lean rats ; and 6 ) the fevers induced by each effective cytokine have different time courses