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CCND1 — IGF2
Text-mined interactions from Literome
Cui et al., Mol Endocrinol 2003
(Breast Neoplasms) :
Second, whereas PR and cyclin D1 are both ER up-regulated,
IGF-I increased
cyclin D1 levels while decreasing PR levels
Hartmann et al., Am J Pathol 2005
(Cerebellar Neoplasms...) :
In GCPs, a synergistic
effect of Shh and
Igf-II on proliferation and gli1 and
cyclin D1 mRNA expression was found
Jiang et al., J Cell Biochem 2006
(Hypertrophy) :
Surprisingly,
IGF-1 activates the expression of both
cyclin D1 and cell-cycle arrest factor, p21Cip1 parallely
Fukushima et al., Endocrinology 2008
:
In contrast,
IGF-I dependent PI 3-kinase activation was
required for the increase in
cyclin D1 mRNA levels and degradation of p27 ( Kip1 )
Jones et al., Mol Cancer Res 2008
(Mammary Neoplasms, Animal) :
Characterization of a novel primary mammary tumor cell line reveals that
cyclin D1 is
regulated by the type I
insulin-like growth factor receptor
Borowiec et al., Biochim Biophys Acta 2011
(Ion Channel Gating) :
As expected,
IGF-1 increased
cyclin D1 and E expression of MCF-7 cells in a cyclic manner, whereas the increase of CDK4 and 2 levels was sustained
Yan et al., Dev Neurobiol 2013
:
Furthermore, 5'-end deletions and mutation analysis of this promoter revealed that a cAMP response element ( CRE ) within -174 base pair ( bp ) upstream of the transcription start site is crucial to the
IGF induced increase in
cyclin D1 transcription