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BDNF — TNF

Text-mined interactions from Literome

Aloe et al., Brain Res 1999 (Nervous System Diseases) : In this study we used two lines of transgenic mice overexpressing tumor necrosis factor alpha (TNF-alpha) in the central nervous system ( CNS ), one characterized by reactive gliosis, inflammatory demyelination and neurological deficits ( Tg6074 ) the other showing no neurological or phenotypical alterations ( TgK3 ) to investigate the effect of TNF-alpha on brain nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) levels and learning abilities
Bayas et al., Cytokine 2002 : In contrast, BDNF expression was reduced by TNF-alpha in human umbilical vein endothelial cells ( HUVEC )
Golan et al., Cereb Cortex 2004 : Moreover, lack of TNFalpha increased the expression of nerve growth factor (NGF), but not brain derived neurotrophic factor (BDNF) , following performance of the learning task
Jornot et al., Rhinology 2007 (Nasal Polyps) : On the other hand, TNFalpha , IL-1beta, and IFN-gamma did not affect DPP-IV activity but significantly increased the cellular expression and the basolateral secretion of BDNF
Saha et al., J Neuroimmune Pharmacol 2006 : Up-regulation of BDNF in astrocytes by TNF-alpha : a case for the neuroprotective role of cytokine ... Activation of NF-kappaB by TNF-alpha and inhibition of TNF-alpha induced BDNF expression by Deltap65 ( a dominant negative mutant ) and NEMO binding domain peptide ( an inhibitor of NF-kappaB ) suggests that TNF-alpha induces BDNF expression through the activation of NF-kappaB ... Among three MAP kinases, TNF-alpha induced BDNF up-regulation was sensitive only to inhibitors of ERK MAP kinase
Lee et al., J Orthop Res 2011 (Intervertebral Disc Degeneration...) : In this study, we investigated the effects of inflammatory cytokines, IL-1ß, and TNF-a , on the expression of an angiogenic factor, vascular endothelial growth factor ( VEGF ), and neurotrophic factors, nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) , in human IVD degeneration ... IL-1ß and TNF-a stimulated the gene expression of VEGF, NGF, and BDNF in nucleus pulposus ( NP ) cells isolated from patient tissues
Bałkowiec-Iskra et al., Neuroscience 2011 (Inflammation) : Tumor necrosis factor-a increases brain derived neurotrophic factor expression in trigeminal ganglion neurons in an activity dependent manner
Lin et al., Journal of neuroinflammation 2011 (Hyperalgesia...) : The cellular mechanism of TNF-a induced BDNF and/or trkB receptor expression was examined in primary DRG cultures collected from pooled L1-L6 DRGs. Calcitonin gene related peptide (CGRP), BDNF and substance P release were also evaluated by enzyme immunoassay