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MET — PRKAB1
Text-mined interactions from Literome
Turban et al., J Biol Chem 2012
:
Expression of a constitutively active AMPK mimicked the effects of AICAR on GU, whereas a dominant interfering AMPK or shRNA silencing of AMPK prevented AICAR stimulated GU and
Met induced
AMPK signaling but only repressed biguanide stimulated GU by ~20 % ... Our findings indicate that although
Met activates
AMPK , a significant component of Met stimulated GU in muscle cells is mediated via an AMPK independent mechanism that involves novel/conventional PKCs
Storozhuk et al., Br J Cancer 2013
(Carcinoma, Non-Small-Cell Lung...) :
Ionising radiation and
MET induced ( i ) sustained activation of
ATM-AMPK-p53/p21 ( cip1 ) and inhibition of Akt-mTOR-4EBP1 pathways in tumours, ( ii ) reduced expression of angiogenesis and ( iii ) enhanced expression of apoptosis markers.Conclusion : Clinically achievable MET doses inhibit NSCLC cell and tumour growth and sensitise them to IR