Lee et al., Biochem Biophys Res Commun 2008
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Itch regulates p45/NF-E2 in vivo by Lys63 linked ubiquitination ... Interestingly, Itch suppressed the transactivation activity of p45/NF-E2 by adding a Lys63 linked polyubiquitin chain
Azakir et al., FEBS J 2010
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Consistently, overexpression of Itch increases cell survival and inhibits caspase 3 activity, whereas downregulation of Itch by RNA interference has the opposite effect, increasing cell death and apoptosis
Schlatter et al., PloS one 2011
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In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the Itch mediated cFLIP degradation and predominantly caspase-8 activation is not involved