Gene interactions and pathways from curated databases and text-mining

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CD46 — IRF6

Text-mined interactions from Literome

Olszyna et al., J Infect Dis 2000 (Endotoxemia) : Sixteen healthy subjects were intravenously injected with lipopolysaccharide (LPS), once with placebo and once with recombinant human interleukin (IL)-10 ( 25 microgram/kg ), to determine the effect of IL-10 on LPS induced production of macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and monocyte chemoattractant protein (MCP)-1
Colotta et al., J Immunol 1992 : The protein synthesis inhibitor cycloheximide ( Cy ) blocked IL-1-, TNF-, or LPS induced MCP gene expression in monocytes
Olszyna et al., Eur Cytokine Netw 2003 (Endotoxemia) : LPS also induced rises in the plasma and RBC levels of monocyte chemoattractant protein (MCP)-1 , which were diminished by IC14
Bosco et al., J Immunol 2004 : Hypoxia also inhibited, in a time dependent fashion, MCP-1 up-regulation by IFN-gamma and LPS
Shi et al., Cell Biochem Biophys 2004 (Atherosclerosis) : We observed constitutive expression of interleukin (IL)-6, IL-8, granulocyte macrophage colony stimulating factor ( GM-CSF ), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1 , cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Lu et al., Invest Ophthalmol Vis Sci 2006 : Triptolide and dexamethasone each inhibited in a concentration dependent manner the LPS induced release of IL-6, G-CSF, MCP-1 , and IL-8 by corneal fibroblasts
Wu et al., Acta Pharmacol Sin 2007 : It was suggested that alkaline extraction-isoelectric precipitated the polysaccharide fraction of A camphorata and had the ability to inhibit LPS induced iNOS, IL-6, IL-10, MCP-5 , and RANTES expression in mouse macrophages
Elizur et al., Am J Respir Cell Mol Biol 2008 : Using a transformed murine Clara cell line ( C22 ), we observed that both LPS and TNF-alpha induced production of keratinocyte derived chemokine ( KC ) and monocyte chemoattractant protein (MCP)-1
Tsai et al., Toxicon 2007 : The K49-PLA markedly reduced LPS stimulated production of NO, MCP-1 , RANTES, and iNOS
Kawanishi et al., Cell Biochem Funct 2008 : It is known that lipopolysaccharide (LPS) induced monocyte chemotactic protein (MCP)-1 secretion from tissues recruits monocytes from the circulation, but the mechanism of the LPS induced MCP-1 production in skeletal muscle is largely unexplained
Bhavsar et al., Thorax 2008 (Asthma) : The inhibition of LPS induced interleukin (IL)1beta, IL6, IL8, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha release by dexamethasone ( 10 ( -6 ) M ) was significantly less in macrophages from patients with severe asthma than in macrophages from patients with non-severe asthma
Schnabl et al., Biochem Biophys Res Commun 2008 (Liver Cirrhosis) : TLR4/MD2 abolished LPS induced secretion of IL-6, IL-8, MCP1 , and RANTES in HSCs
Rosenson et al., Obesity (Silver Spring) 2009 (Metabolic Syndrome X) : In multivariate models including age, gender, and waist circumference, there were inverse correlations between changes in adiponectin and vascular cell adhesion molecule-1 ( VCAM-1 ) ( r = -0.54, P < 0.0001 ) and intercellular adhesion molecule-1 ( ICAM-1 ) ( r = -0.57, P < 0.0001 ), and C-reactive protein (CRP) ( r = -0.40, P = 0.0041 ) ; lipopolysaccharide (LPS) stimulated production of tumor necrosis factor-alpha (TNF-alpha) ( r = -0.30, P = 0.035 ), interleukin (IL)-1beta ( r = -0.44, P = 0.0016 ), monocyte chemotactic protein-1 (MCP-1) ( r = -0.46, P = 0.001 ), and macrophage inflammatory protein-1alpha ( MIP-1alpha ) ( r = -0.45, P = 0.0012 )
Zemans et al., Cell Immunol 2009 : We have shown that the mitogen activated protein kinase ( MAPK ) c-Jun NH ( 2 ) terminal kinase ( JNK ) is activated by LPS in neutrophils and plays a critical role in monocyte chemoattractant protein (MCP)-1 expression and actin assembly
Bayraktar et al., Am J Reprod Immunol 2009 : Interestingly, IL-10 down-regulated LTA mediated MCP1 induction, but not that mediated by LPS
Ramudo et al., Steroids 2010 (Acute Disease...) : Flow cytometry was used to analyze the distribution of the major leukocyte populations, the CD45 expression and the activated state of monocytes as reflected by the membrane bound intercellular adhesion molecule-1 ( ICAM-1 ) and the production of tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattract protein-1 (MCP-1) in response to lipopolysaccaride (LPS)
Yagci et al., J Biol Chem 2010 (Disease Models, Animal...) : Augmented expression of proinflammatory cytokines/chemokines such as TNFalpha, IL-6, and MCP1 and bactericidal nitric oxide production mediated by LPS contribute to the development of EIU
Remppis et al., Mediators Inflamm 2010 : Incubation with Rhizoma coptidis and berberine strongly inhibited LPS induced monocyte chemoattractant protein (MCP)-1 production in RAW cells
Outtz et al., J Immunol 2010 (Inflammation) : Inhibition of Notch signaling decreased induction of the inflammatory cytokines IL-6, IL-12, CXCL10, MCP-1 , monokine induced by IFN-?, and TNF-a in macrophages in response to LPS/IFN-?
Wei et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : Finally, TTM significantly inhibited LPS induced increases of serum levels of soluble ICAM-1, MCP-1 , and TNF-a ( ANOVA, P < 0.05 )
Pang et al., J Hypertens 2012 : In THP-1 cells, telmisartan significantly reduced LPS induced tumor necrosis factor-a, inhibitor of ?B-a, monocyte chemotactic protein-1 (MCP-1) and lectin-like oxidized low-density lipoprotein receptor-1 gene expression and MCP-1 directed migration
Juman et al., Biol Pharm Bull 2012 (Hypertrophy) : CAPE significantly suppressed the levels of lipopolysaccharide (LPS) induced interleukin (IL)-1-beta, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 from a macrophage cell line, RAW264.7
Srivastava et al., Journal of cell communication and signaling 2013 : LPS also caused increased levels of IL-6, IL-8 and MCP1 without exerting any effect on TNF-a, IFN-a or TGF-ß1 at 24 h. Immunofluorescence intensity analysis of confocal microscopy images showed that LPS induced a significant increase in nuclear translocation of NF-?B by 6 h
Song et al., Eur J Pharmacol 2013 (Sepsis) : Intravenous injection of bis-N-norgliovictin 1h before LPS challenge dose-dependently inhibited LPS induced increases in serum levels of TNF-a, IL-6, MCP-1 and IL-10, attenuated liver and lung injury and diminished M1 macrophage polarization in liver