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GATA2 — NOTCH1
Text-mined interactions from Literome
Kumano et al., Blood 2001
(Leukemia, Erythroblastic, Acute) :
These results indicate that
GATA-2 activity is
necessary for the
Notch signaling in hematopoietic cells
Schneider et al., J Pathol 2004
(Burkitt Lymphoma...) :
In some leukaemic cell lines, the effect of
Notch signalling is
mediated by the early transcription factor
GATA-2
Robert-Moreno et al., Development 2005
:
Consistent with a
role for
Notch1 in regulating
Gata2 , we observe increased expression of this gene in 32D cells expressing activated Notch1 ... Taken together, these data strongly suggest that
activation of
Gata2 expression by
Notch1/RBPjkappa is a crucial event for the onset of definitive hematopoiesis in the embryo
Guiu et al., J Exp Med 2013
:
Together, our findings show that
Notch activation in the AGM
triggers Gata2 and Hes1 transcription, and next HES-1 protein represses Gata2, creating an incoherent feed-forward loop required to restrict Gata2 expression in the emerging HSCs