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Hwang et al., J Neurochem 2002
:
These results suggest that NADPH oxidase and nNOS contribute to increased oxidative stress, subsequent activation of PARP/PARG , and neuronal death induced by prolonged neurotrophin exposure
Abdallah et al., Cardiovasc Res 2007
(MAP Kinase Signaling System) :
Inhibition of NAD ( P ) H oxidase with antisense oligonucleotide against the p22(phox) subunit, MEK/ERK signalling with UO 126 ( 30 microM ), or PARP with PJ 34 ( 10 microM ) leads to a marked reduction in hypoxia induced cytosolic Ca2+ load and activation of PARP Czapski et al., Neurochem Int 2013
(Inflammation) :
However, PARP activity had no effect on the mRNA level of COX-2, TNF-a and NADPH oxidase in the hippocampus