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HGF — SLC22A3
Text-mined interactions from Literome
Yang et al., J Am Soc Nephrol 2005
(Fibrosis...) :
Hence,
HGF blocks
EMT by antagonizing TGF-beta1 's action via upregulating Smad transcriptional co-repressor SnoN expression
Zhang et al., American journal of physiology. Renal physiology 2006
(Fibrosis...) :
The
effect of
HGF on
EMT was inhibited by approximately 50 % in the presence of a COX-2 inhibitor SC-58635 ( 10 microM )
Vergara et al., Cancer Lett 2010
(Neoplasm Metastasis...) :
In ovarian cancer
EMT is
induced by transforming growth factor-beta ( TGF-beta ), epidermal growth factor (EGF),
hepatocyte growth factor (HGF) and endothelin-1 (ET-1)
Nagai et al., Mol Cancer Ther 2011
(Carcinoma, Hepatocellular...) :
The downregulation of E-cadherin expression in HepG2 and Huh7 HCC cell lines shows that
HGF mediates the
EMT in HCC
Hung et al., J Agric Food Chem 2011
(Breast Neoplasms...) :
Briefly, our result suggests a connection between FASN activity and c-Met protein expression and that osthole is a potential compound for breast cancer therapy by targeting the major pathway of
HGF/c-Met induced
EMT
Sigurdsson et al., PloS one 2011
:
Endothelial induced
EMT in D492 was partially
blocked by inhibition of
HGF signaling
Zhang et al., J Biol Chem 2012
(MAP Kinase Signaling System) :
CMTM8 overexpression in HepG2 cells inhibited
hepatocyte growth factor induced
EMT-like morphological changes and cell motility
Barcellos et al., J Biol Chem 2013
(Neoplasm Metastasis) :
Cells lacking ARHGAP21 expression show weaker cell-cell adhesions, increased cell migration, and a diminished ability to undergo
hepatocyte growth factor induced
epithelial-mesenchymal transition (EMT)
Savagner et al., J Cell Biol 1997
:
Interestingly, NBT-II cells transfected with antisense Slug cDNA were able to resist
EMT induction by FGF-1 or even
HGF/SF