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IGF2 — STAT3
Text-mined interactions from Literome
Zong et al., J Biol Chem 2000
:
Dominant negative JAK1 or JAK2 was able to block the
IGF-IR mediated tyrosine phosphorylation of
STAT3 in 293T cells
Zhang et al., Mol Cell Biol 2006
:
Overexpression or downregulation of RACK1 greatly enhances or decreases, respectively,
IR/IGF-1R mediated
activation of
STAT3 and its target gene expression
Ray et al., Int J Oncol 2007
(Breast Neoplasms...) :
MCF-7 cells expressed higher levels of Ob-Rb, Jak2, PI3K,
Stat3 and p-Stat3 in a dose dependent manner to 50 ng/ml at 24 h ; and
IGF-IRalpha increased at 24 h. Cyclin D1 and Cox-2 levels increased with leptin treatment
Wang et al., J Biol Chem 2008
:
Interestingly, the expression of the
IGF2 gene and the HGF gene is also
regulated by
JAK2/STAT2/STAT3 , suggesting that this pathway could also promote differentiation by regulating signaling molecules known to be involved in myogenic differentiation