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HGF — SHC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
None
→
HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF)
(modification, collaborate)
Pelicci et al., Oncogene 1995
Evidence: assay
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HRAS/GDP complex (HRAS)
→
HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF)
(modification, collaborate)
Pelicci et al., Oncogene 1995
Evidence: assay
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Pelicci et al., Oncogene 1995
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF)
→
HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF)
(modification, collaborate)
Pelicci et al., Oncogene 1995
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
GRB2/SOS1 complex (GRB2-SOS1)
→
HGF(dimer)/MET(dimer)/p52 SHC/GRB2/SOS1 complex (MET-SHC1-GRB2-SOS1-HGF)
(modification, collaborate)
Pelicci et al., Oncogene 1995
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF)
→
HGF(dimer)/MET(dimer) complex (MET-HGF)
(modification, collaborate)
Saucier et al., Oncogene 2002*, Pelicci et al., Oncogene 1995
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer)/p52 SHC complex (MET-SHC1-HGF)
→
p52 SHC (SHC1)
(modification, collaborate)
Saucier et al., Oncogene 2002*, Pelicci et al., Oncogene 1995
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF(dimer)/MET(dimer) complex (MET-HGF)
→
p52 SHC (SHC1)
(modification, collaborate)
Saucier et al., Oncogene 2002*, Pelicci et al., Oncogene 1995
Evidence: physical interaction
Text-mined interactions from Literome
Day et al., Oncogene 2002
:
IL-4 did not enhance
HGF dependent tyrosine phosphorylation of c-Met or
Shc
Leibowitz-Amit et al., Cancer Res 2006
(Breast Neoplasms) :
The exogenous induction of Mimp at levels similar to its endogenous induction by HGF/SF increases the level of the Met protein and its phosphorylation by HGF/SF but reduces the levels of Shc and prevents the
HGF/SF induced tyrosine phosphorylation of Grb2 and
Shc
Liang et al., Invest Ophthalmol Vis Sci 1998
:
In human corneal epithelial cells, the phosphorylation of adapter protein
Shc ( 52- and 66-kDa isoforms ) was
enhanced by
HGF , but not by KGF