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SHC1 — STAT5A

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT5A — SHC1 (physical association, affinity chromatography technology) Dinerstein-Cali et al., Mol Cell Endocrinol 2000*
• IRef Hprd Interaction: STAT5A — SHC1 (in vitro) Dinerstein-Cali et al., Mol Cell Endocrinol 2000*
• IRef Intact Interaction: STAT5A — SHC1 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013

Text-mined interactions from Literome

Zochodne et al., Oncogene 2000 (Leukemia, Erythroblastic, Acute) : These results suggest that STAT-5 activation, in the absence of Shc/ras activation, plays a role in erythroid differentiation
Lockyer et al., J Immunol 2007 : Here we show in the murine lymphocyte cell line Ba/F3 that low levels of STAT5 activity are essential for Shc signaling