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CA2 — SYT3
Text-mined interactions from Literome
Leveque et al., J Neurochem 2000
:
Our findings are consistent with models in which the
Ca2+ triggered release of
synaptotagmin precedes vesicle fusion
Zhang et al., Neuron 2002
(Calcium Signaling...) :
Ca2+ dependent
synaptotagmin binding to SNAP-25 is essential for Ca2+ triggered exocytosis ... We found that synaptotagmins I and IX associate with SNAP-25 during Ca2+ dependent exocytosis in PC12 cells, and we identified C-terminal amino acids in SNAP-25 ( Asp179, Asp186, Asp193 ) that are required for
Ca2+ dependent
synaptotagmin binding ... These results indicate that the
Ca2+ dependent interaction of
synaptotagmin with SNAP-25 is essential for the Ca2+ dependent triggering of membrane fusion
AraƧ et al., Biochemistry 2003
:
A study showing that phospholipids compete with the neuronal core complex for
Ca2+ dependent binding to the presynaptic Ca2+-sensor
synaptotagmin 1 illustrates the usefulness of the SMRC method in studying multicomponent systems
Jo et al., Yonsei Med J 2006
:
We investigated a type of
Ca2+ dependent
synaptotagmin and Ca2+ signaling in both rat and mouse parotid acinar cells using RT-PCR, microfluorometry, and amylase assay
Pang et al., J Neurosci 2006
:
Using knock-in mice that carry aspartate-to-asparagine substitutions in a Ca2+ binding site of synaptotagmin-1 ( the D232N or D238N substitutions ), we now show that the D232N mutation dramatically increases
Ca2+ dependent SNARE complex binding by native
synaptotagmin-1 , but leaves phospholipid binding unchanged ... These data establish that fast vesicle exocytosis is driven by a dual
Ca2+ dependent activity of
synaptotagmin-1 , namely Ca2+ dependent binding both to SNARE complexes and to phospholipids
Lopez et al., FASEB J 2007
:
Previous studies indicate that the process requires Rab3 dependent tethering of membranes, SNARE complex assembly, and
Ca2+ mediated
activation of
synaptotagmin
Yoon et al., Mol Pharmacol 2007
:
Gbetagamma interferes with
Ca2+ dependent binding of
synaptotagmin to the soluble N-ethylmaleimide-sensitive factor attachment protein receptor ( SNARE) complex
Stein et al., Nature structural & molecular biology 2007
:
Ca2+ dependent binding of
synaptotagmin to its own membrane impedes the activation
Chapman et al., J Biol Chem 1995
:
Ca2+ regulates the interaction between
synaptotagmin and syntaxin 1
Takamori et al., Ann Neurol 1994
(Disease Models, Animal...) :
Findings are similar to those in human Lambert-Eaton myasthenic syndrome and passively transferred Lambert-Eaton myasthenic syndrome in mice, and thus suggest that antibody to a
synaptotagmin-voltage dependent
Ca2+ channel complex may be involved in the pathogenesis of Lambert-Eaton myasthenic syndrome
Kim et al., Proc Natl Acad Sci U S A 1997
:
Binding of
synaptotagmin to the rbA isoform of alpha1A is
Ca2+ dependent , with maximum affinity at 10-20 microM Ca2+