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PTHLH — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Uemura et al., Jpn J Cancer Res 2000
(Carcinoma, Squamous Cell...) :
TNF-alpha or IL-1beta
induced both G-CSF and
PTHrP production in the conditioned medium
Funk et al., Brain Res 2001
(Brain Injuries...) :
To determine whether
PTHrP was
induced in glia by
TNF-alpha , a known mediator of inflammation in brain and of PTHrP induction in peripheral tissues, and to determine whether PTHrP, in turn, mediated inflammatory changes in glia, in vitro studies with rat astrocytes and glial enriched mixed brain cells were also undertaken ...
TNF-alpha induced
PTHrP expression in astrocyte and glial enriched brain cells in vitro, suggesting that this pro-inflammatory peptide was a possible mediator of PTHrP expression in CNS inflammation
Funk et al., J Clin Invest 1993
:
Murine
TNF-alpha and human IL-1 beta, cytokines that mediate many of the effects of LPS, also
increased splenic
PTHrP mRNA levels ... LPS-resistant C3H/HeJ mice, which produce minimal amounts of TNF and IL-1 in response to LPS, were resistant to LPS induction of splenic PTHrP mRNA, while
TNF-alpha and IL-1 beta readily
increased PTHrP mRNA levels in C3H/HeJ mice
Casey et al., J Clin Endocrinol Metab 1993
:
17 beta-Estradiol ( E2 ), interleukin-1 beta (IL-1 beta),
tumor necrosis factor-alpha (TNF alpha) , endothelin-1 (ET-1), transforming growth factor-beta 1 ( TGF beta 1 ), and serum
stimulated PTH-rP production ( evaluated by immunoassay of PTH-rP in the culture medium ) by these cells
Funk et al., J Clin Invest 1998
(Arthritis, Rheumatoid...) :
TNF-alpha and IL-1beta stimulated PTHrP expression in synoviocytes, while dexamethasone and interferon-gamma, agents with some therapeutic efficacy in the treatment of RA,
inhibited PTHrP release