Edwards et al., J Neural Transm 2006
(Alzheimer Disease) :
TNF alpha affects the expression of GFAP and S100B : implications for Alzheimer 's disease
Ponath et al., J Neuroimmunol 2007
:
S100B induced IL-6 and TNF-alpha secretion was blocked by the use of RAGE siRNA specific for knocking down RAGE expression
Figarola et al., Diabetes 2007
(Inflammation) :
These inhibitory effects may be exerted via inhibition of nuclear factor-kappaB (NF-kappaB) activation, as LR-90 suppressed both S100b-and tumor necrosis factor-alpha induced IkappaB-alpha degradation as well as NF-kappaB promoter transcriptional activity
Bianchi et al., Neurobiol Aging 2010
(Encephalitis...) :
We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Piazza et al., Int J Immunopathol Pharmacol 2013
:
Soluble RAGE ( sRAGE ) reduced S100B dependent secretion of TNF-alpha but did not decrease S100B dependent secretion of IL-6