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EIF4EBP1 — EPHB2

Text-mined interactions from Literome

Rao et al., J Biol Chem 1999 : In contrast, inhibition of ERK2 activity by PD 098059 led to a significant loss of PGF2alpha induced eIF4E and 4E-BP1 phosphorylation, global protein synthesis, and bFGF-2 expression ... These findings demonstrate that 1 ) PI3-kinase dependent and independent mechanisms appear to be involved in PGF2alpha induced activation of ERK2 ; 2 ) PGF2alpha induced eIF4E and 4E-BP1 phosphorylation appear to be mediated by both ERK dependent and PI3-kinase dependent rapamycin-sensitive mechanisms ; and 3 ) ERK dependent eIF4E phosphorylation but not PI3-kinase dependent p70 ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC
Kawabata et al., FEBS Lett 2006 (MAP Kinase Signaling System) : These results demonstrate that auraptene targets the translation step for proMMP-7 protein synthesis by disrupting ERK1/2 mediated phosphorylation of 4EBP1 and eIF4B
Sarkar et al., Neuroscience 2010 : Acute E2 application resulted in a rapid, transient increase in phosphorylation of translation initiation factors, ribosomal protein (S6) and eIF4E binding protein1 ( 4EBP1 ), in an activated ERK dependent manner