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EPHB2 — SERPINE1
Text-mined interactions from Literome
Webb et al., J Cell Biol 2001
(Breast Neoplasms) :
ERK phosphorylation was not
induced by tissue-type plasminogen
activator-PAI-1 complex or by uPA-PAI-1 complex in the presence of antibodies that block uPA binding to uPAR
Chang et al., J Biomed Sci 2003
(MAP Kinase Signaling System) :
Based on these results, we suggest that both MEK and
ERK are
involved in the induction of
PAI-1 gene expression during cell adhesion
Hong et al., Translational research : the journal of laboratory and clinical medicine 2006
:
ERK contributes to the effects of Smad signaling on oxidized LDL induced
PAI-1 expression in human mesangial cells
Mukai et al., Am J Physiol Heart Circ Physiol 2007
:
The induction of
PAI-1 by TNF-alpha and insulin is
mediated , in part, by
ERK and p38 MAPK
Onwuegbusi et al., PloS one 2007
(Adenocarcinoma...) :
Inhibiting
ERK and JNK pathways significantly
reduced PAI and uPA induction and inhibited the invasive cell phenotype
Hsieh et al., J Rheumatol 2007
(Osteoarthritis, Knee) :
MAPK
ERK , JNK, and p38 signaling pathways and the PI3K signaling pathway are
involved in upregulation of u-PA,
PAI-1 , and gelatinase expression during early development of knee OA
Pasten et al., Thromb Res 2007
(MAP Kinase Signaling System) :
Inhibitors of
ERK or JNK
prevented polyphenol repression of EC
PAI-1 gene expression
Wickert et al., Comparative hepatology 2007
:
Inhibition of
Erk downstream activation decreased TGF-beta
induced CTGF and
PAI-1 expression to a basal level ... The data provide evidence that beside the TGF-beta-Smad 3 pathway CTGF and
PAI-1 expression is additionally
dependent on
Erk activity in hepatocytes giving new insights into regulation of the profibrogenic proteins
Jerczynska et al., Regul Pept 2009
:
Similarly, CNP and the inhibitors of
ERK1/2 ( PD098059 ) and PI3K ( LY294002 )
attenuated PAI-1 expression induced by TNFalpha
Yuan et al., J Genet Genomics 2011
:
The
ERK kinase inhibitor, U0126, partially
prevented the induction of
PAI-1 by AGEs
Park et al., Mol Cells 2012
:
ERK , which interacts with RHAMM, was
necessary for induction of
PAI-1 by HA