◀ Back to NOTCH3
NOTCH3 — NOTCH4
Text-mined interactions from Literome
Liu et al., Circ Res 2009
:
Interestingly, we found that the expression of
NOTCH3 is
dependent on
Notch signaling, because the gamma-secretase inhibitor DAPT blocked its upregulation
Jiao et al., Clin Exp Immunol 2011
:
Selective inhibition of
Notch signalling
mediated by
Notch3 or Delta-like1 may offer a new strategy for the treatment of RA
Funahashi et al., Vascular cell 2011
:
Overexpression of VEGF induced
Notch4 and the Notch ligand, Dll4,
activated Notch signaling, and altered endothelial cell morphology in a fashion similar to that induced by Notch activation
Serafin et al., J Pathol 2011
(Cell Transformation, Neoplastic...) :
Altogether, these findings indicate that
Notch3 can modulate the tumourigenic properties of CRC cells and
contributes to sustained
Notch activity in DLL4 expressing tumours
Xiang et al., Clinical lymphoma, myeloma & leukemia 2012
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
These facts suggest that downregulating expression of
Notch3 could
attenuate the
Notch signaling activity in T-ALL
Van de Walle et al., J Exp Med 2013
:
Jagged2
induces the strongest
Notch signal through interactions with both Notch1 and
Notch3 , whereas Delta-like 4 primarily binds Notch1