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SOX12 — SOX9
Text-mined interactions from Literome
Wang et al., Cancer Res 2007
(Neoplasm Recurrence, Local...) :
Exogenous
SOX9 expressed at high nonphysiologic levels decreased AR expression and activity ; however, at lower levels,
SOX9 increased AR protein expression
Moniot et al., Development 2009
:
In the mouse XY gonad,
SOX9 upregulates Fgf9, which initiates a Sox9/Fgf9 feedforward loop, and
Sox9 expression is
stimulated by the prostaglandin D2 (PGD2) producing lipocalin prostaglandin D synthase ( L-PGDS, or PTDGS ) enzyme, which accelerates commitment to the male pathway
Reginensi et al., Hum Mol Genet 2011
(Campomelic Dysplasia...) :
At later stages of development,
SOX9 is required to maintain ureteric tip identity and
SOX9 ablation
induces ectopic nephron formation
Lefebvre et al., Mol Cell Biol 1997
(Bone Diseases, Developmental) :
Indeed,
SOX9 binds to a sequence of the minimal Col2a1 enhancer that is essential for activity in chondrocytes, and
SOX9 acts as a potent activator of this enhancer in cotransfection experiments in nonchondrocytic cells