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BCL2 — HGF

Text-mined interactions from Literome

Kosai et al., Hepatology 1999 (Death...) : Moreover, HGF strongly induced Bcl-xL expression and blocked apoptotic signal transduction upstream of CPP32 ( caspase-3 ) in the liver, thereby leading to inhibition of massive hepatocyte apoptosis
Liu et al., Am J Physiol 1999 : To define the mechanism by which HGF inhibits apoptosis, we investigated the effect of HGF on the phosphorylation and expression of the Bcl-2 family proteins
Nomi et al., Biochem Biophys Res Commun 2000 (Liver Failure) : Expression of Bcl-xL and cyclooxygenase-2 (Cox-2) was induced in liver by HGF gene transfer
Nakamura et al., J Clin Invest 2000 (Disease Models, Animal...) : HGF rapidly augmented Bcl-xL expression in injured cardiomyocytes both in vitro and in vivo
Fornoni et al., Am J Pathol 2001 : We investigated whether Bcl-xL and Fas/Fas-ligand were regulated by CsA in cultured podocytes and whether CsA induced apoptosis was prevented by HGF or IGF-I ... HGF , but not IGF-I, prevented apoptosis and restored Bcl-xL levels ... The regulation of Bcl-xL by HGF was mediated by the PI3'-K but not by the MEK-1 pathway
Yamamoto et al., Hypertension 2001 : Of importance, HGF significantly increased Bcl-2 , an inhibitor of apoptosis, in a dose dependent manner under normoxic and hypoxic conditions ( P < 0.01 ), whereas hypoxic conditions resulted in a significant decrease in Bcl-2
Skibinski et al., Eur J Cancer 2001 (Burkitt Lymphoma) : The protection was dose- and time dependent -- maximal protection requiring pre-incubation with 100 ng/ml HGF for 48 h. Western blotting analysis and flow cytometric studies revealed that HGF inhibited doxorubicin- and etoposide induced decreases in the levels of the anti-apoptotic proteins Bcl-X ( L ), and to a lesser extent Bcl-2 , without inducing changes in the pro-apoptotic Bax protein
Zhou et al., Chin Med Sci J 2006 : Whereas HGF significantly promoted the expression of Bcl-2 ( P < 0.01 ) and decreased the activity of caspase-3 ( P < 0.05 ) without affecting Bax level
Zhou et al., Biochem Biophys Res Commun 2006 : HGF significantly promoted the expression of Bcl-2 and NF-kappaB, while decreasing the activities of caspase-3 and -9 without affecting Bax level
Cao et al., Am J Pathol 2009 (Mesothelioma) : Up-regulation of Bcl-xl by hepatocyte growth factor in human mesothelioma cells involves ETS transcription factors
Kosai et al., Biochem Biophys Res Commun 1998 (Hepatic Encephalopathy) : HGF strongly induced Bcl-xL expression and subsequently blocked Fas mediated signaling pathway upstream of CPP32 in the liver