Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
ITGB5
→
ILK
(increases, ITGB5 Activity)
Evidence: Cytohesin-1 contains a PH domain, which binds 3-phosphorylated phosphoinositides, and a sec 7 domain, which binds the 2 tail and possesses guanine nucleotide exchange activity for a small GTP-ase, ARF.122,123 One serine-threonine kinase, p59ILK has been shown to bind to integrin-beta tails, to inhibit beta-1-mediated cell adhesion, and to promote anchorage-independent cell cycle progression and growth of epithelial cells.124