◀ Back to RAC1

RAC1 — TNF

Text-mined interactions from Literome

Sanlioglu et al., J Biol Chem 2001 : Expression of a dominant negative mutant of Rac1 ( N17Rac1 ) reduced Rac1 activation, ROS formation, NFkappaB activation, and TNFalpha secretion following LPS stimulation ... Moreover, studies using CD14 blocking antibodies suggest that Rac1 induces TNFalpha secretion through a pathway independent of CD14
Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : Using the Rac binding domain of PAK ( PAK-RBD ) as an activation-specific probe, here we demonstrate that TNFalpha very rapidly and transiently activates the Rho family GTPase Rac in L929 cells ... The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation
Chen et al., Am J Physiol Heart Circ Physiol 2004 : Expression of dominant negative N17Rac1 by adenovirus suppressed TNF-alpha induced MCP-1 mRNA levels and MCP-1 protein secretion
Ono et al., Arterioscler Thromb Vasc Biol 2004 (MAP Kinase Signaling System) : Overexpression of dominant negative form of CREB suppressed VSMC migration as well as Rac1 expression induced by TNF-alpha ... CREB inhibition suppressed TNF-alpha induced VSMC migration and Rac1 expression
Papaharalambus et al., J Biol Chem 2005 : TNF alpha stimulation of EC increased the membrane association of Rac1 , an event that is essential for Rac1 activity ... TNF alpha also increased the level of GTP-Rac1 , the active form of Rac1, in EC
Shyu et al., J Biomed Sci 2009 : TNF-alpha induced phosphorylation of Rac, while atorvastatin and Rac-1 inhibitor inhibited the phosphorylation of Rac induced by TNF-alpha
Zhang et al., J Cell Mol Med 2011 (Endotoxemia...) : The aim of this study was to investigate the role of Rac1 in TNF-a expression and cardiac dysfunction during endotoxemia and to determine the involvement of phosphoinositide-3 kinase (PI3K) in lipopolysaccharide (LPS) induced Rac1 activation ... We conclude that PI3K mediated Rac1 activation is required for induction of TNF-a expression in cardiomyocytes and cardiac dysfunction during endotoxemia ... The effect of Rac1 on TNF-a expression seems to be mediated by increased NADPH oxidase activity and ERK1/2 phosphorylation
Balasubramanian et al., J Biol Chem 2011 : In addition, TNF-a activation of NF-?B in NIH 3T3 cells is dependent on Rac activation, as evidenced by the inhibition of TNF-a induction of NF-?B mediated transcription by a dominant inhibitory form of Rac1 ... A role for Rac in the inhibitory action of mGBP-2 on NF-?B is further shown by the findings that mGBP-2 inhibits TNF-a activation of endogenous Rac and constitutively activate Rac can restore NF-?B transcription in the presence of mGBP-2
Naikawadi et al., Circ Res 2012 : TNF-a stimulated Rac activation and reactive oxygen species production in a P-Rex1 dependent manner
Shao et al., PloS one 2013 : Caveolin-1 regulates Rac1 activation and rat pulmonary microvascular endothelial hyperpermeability induced by TNF-a
Waheed et al., Mol Biol Cell 2013 : Central role of the exchange factor GEF-H1 in TNF-a induced sequential activation of Rac , ADAM17/TACE, and RhoA in tubular epithelial cells ... Taken together, our findings can explain the mechanisms leading to hierarchical activation of Rac and RhoA by TNF-a through a single GEF
Wu et al., Biochem Pharmacol 2013 (Inflammation) : Chemical or genetic inhibition of ERK5 ablated the statins inhibition of Rac-1 activation, ROS formation, NF-?B, VCAM-1 and ICAM-1 expression induced by TNF-a ... Taken together, statins, via ERK5 activation, suppress TNF stimulated Rac-1 activation, ROS generation, NF-?B activation and VCAM-1 and ICAM-1 expression in human ECs, which provides a novel explanation for the pleiotropic effects of statins that benefit the cardiovascular system
Spencer et al., Am J Physiol Gastrointest Liver Physiol 2013 (Reperfusion Injury) : Cumulatively, these results demonstrate that NOX2 and its activator subunits ( p47(phox) and Rac ) control the secretion of TNF-a by the liver following I/R. Interestingly, in the absence of Kupffer cells and NOX2, NOX1 played a dominant role in TNF-a production following hepatic I/R