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ADAM17 — AKT3

Text-mined interactions from Literome

Murillo et al., Oncogene 2005 : Inhibitors of TACE considerably attenuated Akt activation, which suggests that TGF-beta1 activates EGF signalling in hepatocytes by promoting shedding of EGF-like ligands
Liu et al., Mol Cell 2009 : Inhibition of TACE activity or expression enhanced the cell surface TbetaRI levels and TGF-beta induced Smad3 and Akt activation
Fiorentino et al., Hepatology 2010 (Fatty Liver...) : TACE overexpression significantly impaired insulin dependent phosphorylation of AKT , GSK3, and FoxO1 in mouse hepatocytes
Liu et al., J Biol Chem 2010 : Taken together, our data indicate that ADAM17 mediated activation of Lyn/Akt maintains the viability of U937 cells and that suppression of the pathway is responsible for PILP-1 induced apoptosis
Kommaddi et al., FASEB J 2011 : We show that Trk induced ADAM17 phosphorylation and generation of the p75NTR ( ICD ) is required for neurotrophin induced Erk and Akt activation and for neurotrophin dependent survival signaling