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IL6 — POMC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: POMC → IL6 (increases)
  Evidence: il1 and il6 have been observed to stimulate ACTH synthesis

Text-mined interactions from Literome

Li et al., Mol Cell Endocrinol 1999 : Leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) , two cytokines sharing the common gp130 receptor subunit and functioning through activation of the intracellular JAK/STAT pathway, induce POMC synthesis and ACTH release ... These findings suggest that the ACTH increase induced by LIF and IL-6 is due to both increased POMC synthesis as well as increased POMC processing by up-regulation of PC1
Pereda et al., Exp Clin Endocrinol Diabetes 2000 (Adenoma...) : Here we examined the effects of IL-6 on propiomelanocortin (POMC) expression and ACTH production in corticotroph adenoma cells in vitro
Chida et al., Endocrinology 2005 : Involvement of corticotropin releasing hormone- and interleukin (IL)-6 dependent proopiomelanocortin induction in the anterior pituitary during hypothalamic-pituitary-adrenal axis activation by IL-1alpha ... We found that the induction of proopiomelanocortin (POMC) transcript in the anterior pituitary ( AP ) at 6 h in response to IL-1alpha was reduced in IL-1alpha/beta KO and IL-6 KO mice, as well as in CRH KO mice, suggesting IL-1alpha/beta, IL-6 , and CRH are all required for POMC induction
Zhang et al., Biochem Biophys Res Commun 1995 (Carcinoma, Small Cell...) : The mechanism of ectopic adrenocorticotrophic hormone ( ACTH ) secretion was examined by studies on the effects of corticotropin releasing hormone (CRH), dexamethasone, interleukin (IL)-1 beta and 2, somatostatin, calcium ionophore A23187, 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and 8-bromo-cAMP on pro-opiomelanocortin (POMC) expression and ACTH secretion from a human small cell lung cancer cell line COR-L103