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FLT4 — NOTCH1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes receptor complex:
receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2)
Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996
Text-mined interactions from Literome
Shawber et al., J Clin Invest 2007
(Breast Neoplasms) :
We report that
Notch induces
VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice ... These results demonstrate that Notch1 and VEGFR-3 interact genetically, that
Notch directly
induces VEGFR-3 in blood endothelial cells to regulate vascular development, and that Notch may function in tumor lymphangiogenesis
Domigan et al., Curr Opin Hematol 2012
(Vascular Diseases) :
In particular, we learned how
VEGFR3 regulates
Notch signaling and EphrinB2 coordinates VEGFR2 responses