Yamada et al., Eur J Immunol 1991
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Specifically, cross linking of VLA-5 , but not other members of the VLA family of antigens with the CD3 molecule induced strong CD4 cell activation
Nojima et al., J Exp Med 1990
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These results strongly suggest that CD4 cell activation induced by plasma FN/anti-CD3 may be dependent on both VLA4/CS1 and VLA5/RGDS interactions, although the latter interaction may be required for function of the former