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PARP1 — WRN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: WRN — PARP1 (affinity chromatography technology) Li et al., J Biol Chem 2004*
• IRef Bind_translation Interaction: WRN — PARP1 (coimmunoprecipitation) Li et al., J Biol Chem 2004*
• IRef Biogrid Interaction: WRN — PARP1 (physical association, affinity chromatography technology) Li et al., J Biol Chem 2004*
• IRef Biogrid Interaction: WRN — PARP1 (direct interaction, pull down) Li et al., J Biol Chem 2004*
• MIPS CORUM WRN-Ku70-Ku80-PARP1 complex: WRN-Ku70-Ku80-PARP1 complex complex (PARP1-WRN-XRCC5-XRCC6) Li et al., J Biol Chem 2004*
• IRef Hprd Interaction: WRN — PARP1 (in vivo) Li et al., J Biol Chem 2004*
• IRef Intact Interaction: Complex of PARP1-DDX17-SUPT16H-XRCC5-TOP1-WRN-XRCC6-TMPO (physical association, tandem affinity purification) Sand-Dejmek et al., Molecular cancer 2011
• IRef Intact Interaction: Complex of 248 proteins (association, pull down) von Eyss et al., EMBO J 2012
• IRef Intact Interaction: Complex of 25 proteins (association, anti bait coimmunoprecipitation) Li et al., J Biol Chem 2004*
• IRef Intact Interaction: WRN — PARP1 (physical association, anti tag coimmunoprecipitation) Li et al., J Biol Chem 2004*
• IRef Intact Interaction: WRN — PARP1 (direct interaction, anti tag coimmunoprecipitation) Li et al., J Biol Chem 2004*
• IRef Intact Interaction: WRN — PARP1 (physical association, anti bait coimmunoprecipitation) Adelfalk et al., FEBS Lett 2003*
• IRef Intact Interaction: Complex of PARP1-WRN-XRCC6 (physical association, molecular sieving) Li et al., J Biol Chem 2004*

Text-mined interactions from Literome

von Kobbe et al., Nucleic Acids Res 2004 : Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein ... The differential effect of PARP-1 and PARP-2 on WRN catalytic activity was not due to differences in affinity for WRN or the DNA substrate
Popp et al., ACS Chem Biol 2013 (Werner Syndrome) : It was previously shown that WRN interacts with PARP1 and that WRN activity is inhibited by PARP1