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TP53 — UCHL1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yu et al., Hepatology 2008
(Carcinoma, Hepatocellular...) :
Moreover,
UCHL1 directly interacts with p53 and
stabilizes p53 through the ubiquitination pathway
Xiang et al., PloS one 2012
(Breast Neoplasms) :
Subcellular localization study showed that
UCHL1 increased cytoplasmic abundance of
p53 ... We further found that
UCHL1 induced
p53 accumulation and reduced MDM2 protein level, and subsequently upregulated the expression of p21, as well as cleavage of caspase3 and PARP, but not in catalytic mutant UCHL1 C90S expressed cells