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MMP2 — SPARC

Text-mined interactions from Literome

Fujita et al., J Oral Pathol Med 2002 : SPARC stimulates the synthesis of OPG/OCIF, MMP-2 and DNA in human periodontal ligament cells ... Hp-SPARC also enhanced DNA and MMP-2 synthesis dose-dependently, but had little effect on ALPase activity and SPARC mRNA expression
McClung et al., Neurosci Lett 2007 (Brain Neoplasms...) : SPARC upregulates MT1-MMP expression, MMP-2 activation, and the secretion and cleavage of galectin-3 in U87MG glioma cells ... We have shown by cDNA array analysis that SPARC upregulates membrane type 1-matrix metalloproteinase ( MT1-MMP ) and matrix metalloproteinase-2 (MMP-2) transcripts
Shankavaram et al., J Cell Physiol 1997 : Because SPARC and monocytes/macrophages are prevalent at sites of inflammation and remodeling in which there is connective tissue turnover, we examined the effect of SPARC on monocyte matrix metalloproteinase ( MMP ) production
Gilles et al., Cancer Res 1998 (Breast Neoplasms...) : SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines ... In this study, we show that SPARC/osteonectin , a small ECM associated matricellular glycoprotein, can induce MMP-2 activation in two invasive breast cancer cell lines ( MDA-MB-231 and BT549 ) but not in a noninvasive counterpart ( MCF-7 ), which lacks MT1-MMP ... We did, however, detect decreased levels of TIMP-2 protein in the media of cells incubated with peptide 1.1 or recombinant SPARC ; thus, the induction of MMP-2 activation by SPARC might be due in part to a diminution of TIMP-2 protein ... We conclude that SPARC , and specifically its NH2-terminal domain, regulates the activation of MMP-2 at the cell surface and is therefore likely to contribute to the proteolytic pathways associated with tumor invasion