◀ Back to E2F1
CCNE2 — E2F1
Pathways - manually collected, often from reviews:
-
KEGG Cell cycle:
Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2
→
CCNE1/CCNE2
(gene expression, expression)
Text-mined interactions from Literome
Suzuki et al., Int J Cancer 2000
(Mouth Neoplasms...) :
TSA
enhanced the protein expression of p21 ( WAF1 ), CREB binding protein,
cyclinE , cyclin A, Bak and Bax, while it reduced the expression of
E2F-1 , E2F-4, HDAC1, p53 and hyperphosphorylated form of Rb
Duronio et al., Genes Dev 1995
:
Instead,
cyclin E expression
activates E2F in the CNS
Chiarugi et al., Cell Mol Biol Res 1994
:
Notably, both of the two giant regulators of checkpoint 1 ( i.e., p105RB [ retinoblastoma oncosuppressor encoded protein ] and p53 dependent WAF1/CIP1 ) are influenced by or influence G1 cyclins :
cyclin E/cdk2 kinase complexes hyperphosphorylate p105RB,
induce E2F release, and free G1 exit