Kim et al., Mol Cell Biol 2007
(Cell Transformation, Neoplastic) :
This study places IGF-IR among a small group of oncogenes that, when overexpressed alone, can confer in vivo tumorigenic growth of MCF10A cells and indicates the hierarchy in the mechanism of IGF-IR induced EMT Walsh et al., Cell communication and signaling : CCS 2011
:
IGF-1 treatments were then followed by the addition of latent-TGF-ß1 to determine if elevated levels of IGF-1 together with latent-TGF-ß1 could cause EMT