◀ Back to SGK1
PIK3CA — SGK1
Pathways - manually collected, often from reviews:
-
WikiPathways Insulin Signaling:
Complex of IRS1-PIK3CA
→
GSK3B/AKT2/AKT1/SGK3/SGK1/GSK3A/PDPK1/SGK2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., American journal of physiology. Renal physiology 2001
:
In A6 kidney cells, mineralocorticoid induction of the phosphorylated form of SGK preceded the increase in Na+ transport, and specific inhibition of
PI3K inhibited both phosphorylation of
SGK and mineralocorticoid induced Na+ transport
Yan et al., Biochem J 2008
:
The
activation of the AGC ( protein kinase A/protein kinase G/protein kinase C ) -family kinase
SGK1 ( serum- and glucocorticoid induced kinase 1 ) by insulin via
PI3K ( phosphoinositide 3-kinase ) signalling has been appreciated for almost 10 years
Miller et al., Breast Cancer Res 2011
(Breast Neoplasms...) :
PI3K activates AKT,
serum/glucocorticoid regulated kinase ( SGK ), phosphoinositide dependent kinase 1 ( PDK1 ), mammalian target of rapamycin (mTOR), and several other molecules involved in cell cycle progression and survival