◀ Back to CXCL12
CXCL12 — MMP2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MMP2
→
CXCL12
(increases, CXCL12 Activity)
Evidence: We found that Slit also inhibits CXCL12-induced phosphatidylinositol 3-kinase, p44/42 MAP kinase, and metalloproteinase 2 and 9 activities.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yu et al., J Bone Miner Res 2003
(Bone Resorption) :
SDF-1 versus RANKL
effects on chemotaxis, transcollagen migration,
MMP-9 expression and activity, OC development, and bone resorption were evaluated in RAW cells or RAW-OCs
Singh et al., Lab Invest 2004
(Neoplasm Invasiveness...) :
CXCL12 increased
MMP-2 expression by LNCaP and PC3 ; however, MMP-9 expression was elevated only in PC3 cells after CXCL12-CXCR4 ligation
Su et al., Zhonghua Yi Xue Za Zhi 2005
(Lung Neoplasms...) :
SDF-1a , a CXCR4 specific ligand, induced the migratory response and F-actin polymerization in the lung cancer cells ; SDF-1a
promoted the
MMP-2 activity, the adhesion to vascular endothelial cells and GRO-a expression ; and neutralizing CXCR4 antibody inhibited these effects to some degree
Zhang et al., Carcinogenesis 2005
(Glioblastoma...) :
We found that
SDF-1alpha increased the expression of membrane type-2 matrix metalloproteinase ( MT2-MMP ), but not the other MT-MMPs,
MMP-2 or MMP-9
Ries et al., Blood 2007
(Inflammation) :
Moreover, the inflammatory cytokines TGF-beta1, IL-1beta, and TNF-alpha up-regulated MMP-2, MT1-MMP, and/or MMP-9 production in these cells, resulting in a strong stimulation of chemotactic migration through ECM, whereas the chemokine
SDF-1alpha exhibited minor
effects on
MMP/TIMP expression and cell invasion
Yuecheng et al., Eur J Cancer Prev 2007
(Neoplasm Invasiveness...) :
Stromal-cell derived factor-1 regulates epithelial ovarian cancer cell invasion by activating matrix metalloproteinase-9 and
matrix metalloproteinase-2 ... Moreover,
SDF-1-CXCR4 interaction
activated MMP-9 at the both transcription and protein levels and
MMP-2 only at the post-translation level
Hu et al., Cancer Sci 2008
(Neoplasm Invasiveness...) :
Furthermore, in contrast to CXCL12, which enhanced the activity of matrix metalloproteinase (MMP) 9 and MMP2 in PC3 and LNCap,
CXCL16 ligation
resulted in stronger MMP9 and
MMP2 activity in LNCap but not in PC3
Zhou et al., Hum Reprod 2008
:
CXCL12 induced an apparent increase in the invasiveness of trophoblasts ( P < 0.01 ), and
up-regulated matrix metalloproteinase (MMP) 9 and
MMP2 activity of both trophoblasts and DSCs ( both P < 0.01 ) in an autocrine and paracrine manner
Jovanović et al., Reproduction 2010
:
Exogenous
IL8/CXCL8 increased trophoblast cell migration and invasion, which may be partly attributable to stimulation of
MMP2 and MMP9 levels and an increase in integrins
Laird et al., Hum Reprod 2011
:
Expression of
CXCL12 and CXCR4 in human endometrium ;
effects of CXCL12 on
MMP production by human endometrial cells ... The aim of this study was to investigate CXCL12 and CXCR4 expression in human endometrium and to see if
CXCL12 could
affect matrix metalloproteinase ( MMP ) production by endometrial stromal and epithelial cells ...
CXCL12 ( 10 and 100 ng/ml )
had no effect on mRNA expression or activity of
MMP-2 or MMP-9 in either stromal or epithelial cells ... In contrast to its effects in other cells,
CXCL12 had no effect on
MMP-2 or MMP-9 production by endometrial stromal or epithelial cells ... In contrast to its effects in other cells,
CXCL12 had no effect on
MMP-2 or MMP-9 production by endometrial stromal or epithelial cells
Du et al., Hum Reprod 2012
:
CsA up-regulated
CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely
inhibited the CsA induced increase in cell number, invasion and MMP-9 and
MMP-2 activity of cytotrophoblast
Takekoshi et al., Mol Cancer Ther 2012
(Lung Neoplasms...) :
In vitro analysis of amino-terminal cleavage by enzymes dipeptidylpeptidase IV ( DPPIV/CD26 ) and
matrix metalloproteinase-2 (MMP-2) resulted in 25-fold and 2-fold slower degradation rates, respectively, of
CXCL122 compared with wtCXCL12
Maddirela et al., Int J Oncol 2013
(Glioblastoma...) :
External supplementation of either rhMMP-2 or rhSDF-1 counteracted and noticeably reversed pM.si inhibited SDF-1, CXCR4, phospho-PI3K and phospho-AKT expression levels and angiogenesis, thereby confirming the
role of
MMP-2 in the regulation of avß3 mediated
SDF-1/CXCR4 signaling ... Collectively, our data demonstrate the
role of
MMP-2 in the regulation of
SDF-1/CXCR4 signaling mediated angiogenesis in ECs and show the anti-angiogenic efficacy of combining MMP-2 downregulation and IR when treating patients with GBM in the future
Pan et al., Mol Biol Rep 2013
(MAP Kinase Signaling System...) :
SDF-1a induced
MMP-2 and MMP-9 upregulation in PANC-1 and SW-1990 cells, which was associated with increased pancreatic cancer cell proliferation and invasion ... Furthermore,
SDF-1a induced p38 phosphorylation and p38 inhibition
reduced both the level of SDF-1a stimulated
MMP-2 expression and PANC-1 cell invasion ... Overall, our results demonstrate that
SDF-1a/CXCR4 upregulates
MMP-2 expression and induces pancreatic cancer cell invasion in PANC-1 and SW-1990 cell lines by activating p38 MAPK
Zhang et al., Hum Reprod 2013
:
However,
CXCL6 inhibited trophoblast cell migration and invasion by
suppressing MMP-2 activity in human first-trimester interface