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EGF — PLAU

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PLAU → EGF (increases, EGF Translocation)
  Evidence: (4) the EGF-induced cell migration was statistically higher inAR negative than in AR positive cells with a similar increase with respect to basal value (about 2.6 fold); (5) the Matrigel invasion was statistically higher in AR negative than in AR positive PCa cells also if the increment of Matrigel invasion after EGF treatment was statistically higher in AR positive respect to AR negative cells; (6) the EGF induced uPA secretion and its membrane uptake through the increment of uPAR;

Text-mined interactions from Literome

Park et al., Biol Reprod 1999 : The uPA activity in oocytes was not detected when they were cultured without cumulus cells in either the presence or absence of EGF, although cumulus expansion was stimulated by EGF , exhibiting a time-course similar to that observed in PA production
Shiratsuchi et al., J Cell Physiol 2002 (Carcinoma, Squamous Cell...) : EGF also induced increased expression of uPA and uPA receptor (uPAR) proteins and mRNA, as well as transcription factor activator protein-1 (AP-1)-DNA binding ... Moreover, transfection of SCC cells with AP-1 decoy oligodeoxynucleotides ( ODNs ) resulted in the suppression of EGF induced uPA and uPAR expression and Matrigel invasion
Unlü et al., Int J Biol Markers 2003 (Neoplasm Invasiveness...) : EGF increased uPA protein level and uPA activity in both cell types
Mahabeleshwar et al., J Biol Chem 2004 (Anoxia...) : DN Lck and inhibitors of Lck, EGF receptor, and MEK-1 suppressed H/R induced uPA secretion and cell motility
Smith et al., J Periodontal Res 2004 (MAP Kinase Signaling System) : In this study, we have assessed the effect of EGF on uPA expression in primary cultures of human gingival fibroblasts ... Our data also shows that EGF stimulated uPA production involves the activation of the extracellular signal regulated kinases 1/2 and JNK signaling pathways and might be modulated by the natural phytoestrogens curcumin and genistein
Zhang et al., Pancreas 2006 (Neoplasm Invasiveness...) : Subsequently, the EGF induced MMP-9 and uPA expression and MMP-9 activity, as well as cell invasiveness, were also inhibited by these NF-kappaB inhibitors
Cáceres et al., J Cell Biochem 2008 (Neoplasm Invasiveness...) : Moreover, we found that exogenously added uPA stimulates autocrine production of HB-EGF , and that blocking HB-EGF activity curbed DU-145 cell invasive potential
Zhang et al., Zhonghua Zhong Liu Za Zhi 2007 (Neoplasm Invasiveness...) : Subsequently, the EGF induced uPA expression and invasiveness were also inhibited by NF-kappaB inhibitor
Amos et al., J Neuropathol Exp Neurol 2010 (Glioblastoma...) : Here, we characterized the signal transduction pathway ( s ) by which EGF regulates uPA expression and promotes astrocytoma invasion ... Similarly, mutations in the activator protein 1 binding site of the uPA promoter reduced EGF induced increases in uPA promoter activity ... In summary, these results suggest that c-Src, mitogen activated protein kinase, and a composite activator protein 1 on the uPA promoter are responsible for EGF induced uPA expression and GBM invasion
Harvey et al., Development 1995 : Both LIF and EGF stimulated uPA and MMP-9 activity in blastocyst outgrowths after 3 days of culture ( day 7 )
Long et al., Cancer Lett 1996 (Breast Neoplasms...) : EGF increased uPA secretion from both cell lines, as determined by ELISA and zymography, and this correlated with increased expression of uPA mRNA
Bany et al., Mol Reprod Dev 1998 : Finally, EGF caused an increase in the steady-state uPA mRNA levels in the cells ... These results provide evidence that EGF causes an increase in the secretion of uPA by rat endometrial stromal cells from uteri sensitized for the decidual cell reaction through a mechanism that involves an increase in steady-state uPA mRNA levels
Watabe et al., Int J Cancer 1998 (Breast Neoplasms...) : Here, we have identified transcriptional requirements for the induction of uPA and 92 kDa type IV collagenase by epidermal growth factor (EGF) ... Reporter transfection assays revealed the activation of uPA and MMP-9 collagenase promoters by EGF and the requirement of each of the composite Ets and AP-1 transcription factor binding sites for an EGF response ... Most notably, transfections with the Ets-1 and Ets-2 expression vectors potentiated uPA and MMP-9 promoter activation in response to EGF