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PTGS2 — PTHLH
Text-mined interactions from Literome
Yoshida et al., J Clin Endocrinol Metab 2001
(Arthritis, Rheumatoid) :
The IL-1alpha induced
PTHrP production was
inhibited by PG H synthetase ( Cox ) inhibitors, indomethacin, and also by
Cox-2 inhibitor, NS398
Saito et al., Cancer Sci 2007
(Cachexia...) :
These results demonstrate that production of PTHrP and IL-6 largely depends on the microenvironments in which tumors are developed or metastasized and that up-regulation of
COX-2 in a necrobiotic environment
leads to
PTHrP production, thereby causing cachectic syndromes