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CPOX — UCP1

Text-mined interactions from Literome

Kiritoshi et al., Diabetes 2003 (Diabetes Mellitus, Experimental...) : Similarly, incubation of HMCs with 30 mmol/l glucose significantly increased mitochondrial membrane potential, intracellular ROS production, COX-2 protein expression, and PGE2 synthesis, and these events were completely suppressed by thenoyltrifluoroacetone or carbonyl cyanide m-chlorophenylhydrazone, inhibitors of mitochondrial metabolism, or by overexpression of uncoupling protein-1 or manganese superoxide dismutase
Madsen et al., PloS one 2010 : Here we report that cyclooxygenase (COX) activity and prostaglandin E ( 2 ) ( PGE ( 2 ) ) are crucially involved in induction of UCP1 expression in inguinal white adipocytes, but not in classic interscapular brown adipocytes ... Inhibition of COX activity attenuated diet induced UCP1 expression and increased energy efficiency and adipose tissue mass in obesity-resistant mice kept at thermoneutrality