Arlander et al., Cancer Res 2008
:
Furthermore, in agreement with the checkpoint attenuation, DNA-PK inhibition in ATM-knockdown cells resulted in reduced signaling of the checkpoint kinase CHK1 as evidenced by reduced CHK1 phosphorylation
Durkin et al., J Biol Chem 2008
:
Tax containing nuclear extracts showed increased DNA-PK activity, and specific inhibition of DNA-PK prevented Tax induced activation of Chk2 kinase activity