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EGF — LPA

Text-mined interactions from Literome

Guo et al., J Urol 2000 (Prostatic Neoplasms) : Inhibition of EGF- and LPA- induced ERK activation with the EGF receptor inhibitor, AG1478, or the MEK inhibitor, PD98059, attenuated their proliferative effects
Hirata et al., Biochem Biophys Res Commun 2001 : These mutant forms showed resistance to stimuli of both TPA and LPA, suggesting that proHB-EGF is cleaved at the similar site by stimulation with TPA and LPA
Wu et al., Biochim Biophys Acta 2002 : In this article, we review recent progress in the study of trans-regulation of EGF receptor by LPA and G protein coupled receptors ( GPCR ) and discuss the gap in our knowledge of the mechanism by which LPA induces EGF receptor activation
Toews et al., Biochim Biophys Acta 2002 (Asthma...) : Recent studies of the molecular components and signaling pathways mediating synergism are described, including LPA induced upregulation of EGF receptors and activation of multiple transcription factors by both LPA and EGF
Santiskulvong et al., Exp Cell Res 2003 : Galardin ( GM 6001 ), a broad-spectrum matrix metalloproteinase inhibitor, blocks bombesin- and LPA induced EGF receptor transactivation and DNA synthesis in rat-1 cells
Menard et al., Cell Signal 2003 : Activation of PAK1 by LPA was independent of PI3-kinase and the EGF receptor, but was inhibited by dominant negative RhoA
Yamashita et al., J Surg Oncol 2006 (Adenocarcinoma...) : Since LPA can transactivate HGF receptor ( c-Met ) as well as EGF-receptor , LPA may promote the progression of gastric cancer in diffuse-type with high expression of c-Met
Xu et al., Invest Ophthalmol Vis Sci 2007 : The release of HB-EGF assessed by AP activity increased significantly in response to wounding, LPA , or both, and the release of HB-EGF-AP induced by LPA was inhibited by PP2 and GM6001
De Kimpe et al., Cell Signal 2009 : Moreover, there was no effect of PKD mediated cortactin phosphorylation on EGF receptor degradation and LPA induced migration
Snider et al., Am J Physiol Cell Physiol 2010 (Ovarian Neoplasms) : PD158780, an EGFR-selective tyrosine kinase inhibitor, blocks LPA production in response to both EGF and LPA in OVCAR3 and SKOV3 cells ... Pertussis toxin, an inhibitor of LPA receptor signaling, inhibits LPA production in response to both EGF and LPA ... Overexpression of PLD2 increases LPA production, while knockdown of PLD2 blocks EGF induced LPA production ... A phospholipase A2 (PLA2) inhibitor also blocks LPA- and EGF induced LPA production ... These results indicate that EGF stimulates LPA production in a manner that requires PLD2, and suggest that cross-talk can occur bidirectionally between EGF and LPA receptors
Colín-Santana et al., Biochim Biophys Acta 2011 : EGF diminished LPA mediated intracellular calcium response and induced LPA ( 1 ) receptor phosphorylation, which was sensitive to protein kinase C inhibitors ... Angiotensin II and LPA induced EGF receptor transactivation as evidenced by Akt/PKB phosphorylation through metalloproteinase catalyzed membrane shedding of heparin binding EGF and autocrine/paracrine activation of EGF receptors
Arimura et al., Life Sci 1998 : An EGF receptor mediated signal attenuates the inhibitory effect of LPA on an adenylate cyclase activity