◀ Back to IKBKG
IKBKG — PLK1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Higashimoto et al., J Biol Chem 2008
:
Expressing a constitutively active
Plk1 in mammalian cells
reduced tumor necrosis factor (TNF) induced
IKK activation, resulting in decreased phosphorylation of endogenous IkappaBalpha and reduced NF-kappaB activation ... Knocking down
Plk1 in mammalian cells
restored TNF induced
IKK activation in nocodazole treated cells
Zhang et al., Mol Biol Cell 2010
:
We describe a new regulatory mechanism for PLK1 :
PLK1 negatively
regulates TNF induced
IKK activation by inhibiting the ubiquitination of NEMO