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IKBKG — REL

Pathways - manually collected, often from reviews:

• Reactome Reaction: IKBKG → REL (reaction) Burke et al., J Biol Chem 1999, Whiteside et al., EMBO J 1997, Li et al., Mol Cell Biol 1997, Zandi et al., Science 1998, Heilker et al., Eur J Biochem 1999
• WikiPathways Toll-like Receptor Signaling: Complex of IKBKB-CHUK-IKBKG → Complex of NFKB1-NFKB2-RELA-RELB-REL (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 25 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 16 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 11 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 11 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 11 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of FBXW7-NFKB2-REL-MAP3K14-USP2-RELA-IKBKG-IKBKB Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of IKBKB-IKBKAP-REL-NFKBIA-IKBKG-MCM5-NFKB2-MCM7-RELA Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 21 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of RELB-REL-TNIP2-NFKB1-RELA-NFKBIA-NFKB2-IKBKG-NFKB1 Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2): TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) complex (CHUK-IKBKG-KPNA3-NFKB1-NFKB2-NFKBIA-NFKBIB-NFKBIE-REL-RELA-RELB-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2): TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) complex (CHUK-FBXW7-IKBKB-IKBKG-MAP3K14-NFKB2-REL-RELA-SEC16A-USP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex: CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex complex (CHUK-COPB2-IKBKG-NFKB1-NFKB2-NFKBIA-NFKBIE-REL-RELA-SPAG9-TNIP1-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I): TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM TNF-alpha/NF-kappa B signaling complex 5: TNF-alpha/NF-kappa B signaling complex 5 complex (CD3EAP-CHUK-CUL1-FBXW11-IKBKB-IKBKG-IQGAP2-KPNA2-LRPPRC-MCC-MTIF2-NFKB1-NFKB2-NFKBIB-PDCD2-POLR1A-POLR1B-POLR1D-POLR1E-POLR2H-POLR2L-RASAL2-REL-RELA-SKP1) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 11 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 26 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 18 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 13 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Corum Interaction: Complex of 13 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 101 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 290 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 145 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 145 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: Complex of 626 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004

Text-mined interactions from Literome

Weber et al., Gastroenterology 2000 : NF-kappaB/Rel activity induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB inducing kinase, IKK-alpha, IKK-beta , or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine
Hansberger et al., J Virol 2007 : Collectively, these findings indicate a novel pathway of NF-kappaB/Rel activation involving IKKalpha and IKKgamma/Nemo , which together mediate the expression of downstream proapoptotic genes in reovirus infected cells
Garbati et al., Gene Expr 2008 : Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro : evidence that IKK does not directly enhance GAL4-REL transactivation ... We also show that the previously reported effects of overexpressed IKK and tumor necrosis factor treatment on GAL4-REL transactivation are due to IKK mediated activation of the endogenous NF-kappa B pathway, which increases transcription from kappa B sites in the promoter of a commonly used GAL4 expression vector