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FOXP3 — IL17D

Text-mined interactions from Literome

Huber et al., Int Immunol 2008 : Our results demonstrate that IL-27 inhibits the acquisition of the Treg phenotype at the level of Foxp3 , CD25 and CTLA-4 ( CD152 ) expression as well as the suppressive function
Batten et al., J Immunol 2008 : Cutting edge : IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
Cox et al., J Exp Med 2011 (Colitis) : Indeed, IL-27 suppressed Foxp3 induction in vitro and in an ovalbumin dependent tolerization model in vivo
Wojno et al., J Immunol 2011 (Inflammation) : Although previous studies have shown that regulatory T cells ( Tregs ) express the IL-27R, and that IL-27 inhibits forkhead box P3 upregulation in vitro, little is known about how IL-27 influences Tregs in vivo ... Although IL-27 did not cause mature Tregs to downregulate forkhead box P3 , transgenic overexpression in vivo limited the size of a differentiating Treg population in a bone marrow chimera model, which correlated with reduced production of IL-2, a vital cytokine for Treg maintenance