Zhou et al., Mutagenesis 2003
(Colonic Neoplasms) :
This study suggests that decreased COX activity is likely due to post-transcriptional regulation of the COXII subunit by p53 Piazza et al., Cancer Res 1997
(Adenocarcinoma...) :
The biochemical pathway does not require COX inhibition or p53 induction and appears to be fundamentally different from the apoptotic response to 5-FU