◀ Back to BMP2
BMP2 — CHRD
Pathways - manually collected, often from reviews:
-
BioCarta alk in cardiac myocytes:
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
→
CHORDIN (CHRD)
(modification, activates)
-
KEGG TGF-beta signaling pathway:
CHRD
→
AMH/BMP2/BMP4/BMP5/BMP6/BMP7/BMP8A/BMP8B/GDF5/GDF6/GDF7
(protein-protein, inhibition)
-
NCI Pathway Database BMP receptor signaling:
CHRD (CHRD)
→
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
CHRD (CHRD)
→
BMP2-4 (homodimer) complex (BMP4_BMP2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
CHRD (CHRD)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMP2-4 (homodimer) complex (BMP4_BMP2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMP2-4/BMPR2/BMPR1A-1B/RGM complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
RGM family (RGMB/RGMA/HFE2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP2-4/CHRD complex (BMP4_BMP2-CHRD)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Nohe et al., J Biol Chem 2002, Samad et al., J Biol Chem 2005, Babitt et al., J Biol Chem 2005, Babitt et al., Nat Genet 2006, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Nohno et al., J Biol Chem 1995, Liu et al., Mol Cell Biol 1995, Suzuki et al., Proc Natl Acad Sci U S A 1994, ten Dijke et al., J Biol Chem 1994, Koenig et al., Mol Cell Biol 1994, Piccolo et al., Cell 1996
Evidence: mutant phenotype, physical interaction, other species
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Connors et al., Development 1999
(Limb Deformities, Congenital) :
At this time, unimpeded
Chordin may diffuse to the most ventral marginal regions and
inhibit high
Bmp activity levels
Blitz et al., Dev Biol 2000
:
We examine the possibility that
chordin , a secreted
inhibitor of
bone morphogenetic protein ( BMP ) signaling and candidate `` dorsalizing signal, '' is a long-range acting factor
Darras et al., Dev Biol 2001
:
( 3 ) At the tailbud stage, among these pigment cell precursors, BMPb induces the differentiation of specifically the anterior type of pigment cell, the otolith ; while posteriorly,
CHORDIN suppresses
BMP activity and allows ocellus differentiation
Wagner et al., Dev Biol 2002
:
As has been proposed for the fly orthologue of chordin, short gastrulation, our paradoxical results can be explained by a model whereby
Chordin both antagonizes and
promotes BMP activity
Quint et al., Proc Natl Acad Sci U S A 2002
:
The effects of shh ectopic expression could be antagonized by ectopic expression of
chordin , an
inhibitor of
bone morphogenetic protein ( bmp ) signaling
Jasuja et al., J Biol Chem 2004
:
The secreted protein Twisted Gastrulation ( TSG ) is thought to help shape BMP signaling gradients by acting as a cofactor that enhances
Chordin inhibition of
BMP signaling
Moll et al., FASEB J 2006
(Neoplasm Invasiveness...) :
We previously reported the expression of human
chordin (CHRD) , a
BMP extracellular
regulator , in the ovary
Canty et al., J Biol Chem 2006
:
Similarly, the activity of
BMP-2/4 ( vertebrate homologues of DPP ) is
augmented by cleavage of
chordin
Zhang et al., J Biol Chem 2007
:
The present results show that
chordin , CHL2, and CV2
regulate BMP-2 signaling by different recognition mechanisms
Olivares et al., Dev Biol 2009
:
Overexpression of Xenopus Syn1 ( xSyn1 ) mRNA is sufficient to reduce
BMP signaling,
induce chordin expression and rescue dorso-ventral patterning in ventralized embryos
Soofi et al., J Am Soc Nephrol 2013
(Acute Kidney Injury...) :
The secreted
kielin/chordin-like ( KCP ) protein, one of a family of cysteine-rich proteins, suppresses TGF-ß signaling by sequestering the ligand from its receptor, but it
enhances bone morphogenetic protein ( BMP ) signaling by promoting ligand-receptor interactions
Streit et al., Development 1998
:
These results suggest that the
regulation of
BMP signalling by
chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue