◀ Back to MAPK14
MAP2K4 — MAPK14
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK14
→
MAP2K4
(increases, MAP2K4 Activity, MAPK14 Activity)
Chen et al., J Biol Chem 2001*
Evidence: the protein kinase TAO2 activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase and c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
-
BioCarta mapkinase signaling pathway:
MKK7/MEK4 (MAP2K7/MAP2K4)
→
MAPK11/ERK6/MAPK13/p38 (MAPK14/MAPK13/MAPK12/MAPK11)
(modification, activates)
-
NCI Pathway Database Regulation of p38-alpha and p38-beta:
MKK4 (MAP2K4)
→
p38 alpha (MAPK14)
(modification, activates)
Han et al., J Biol Chem 1993*, DĂ©rijard et al., Science 1995*, Han et al., Science 1994*, Lee et al., Nature 1994*
Evidence: mutant phenotype, assay, other species
-
WikiPathways MAPK Cascade:
MAP2K3/MAP2K4
→
MAPK14/MAPK12
(activation)
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MAP2K4
→
MAPK14
(activation)
-
WikiPathways p38 MAPK Signaling Pathway:
MAP2K4
→
MAPK14
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK14
(direct interaction, enzymatic study)
Deacon et al., J Biol Chem 1997
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK14
(direct interaction, pull down)
Xia et al., Genes Dev 1998*
-
IRef Biogrid Interaction:
MAP2K4
—
MAPK14
(physical association, affinity chromatography technology)
Xia et al., Genes Dev 1998*
-
IRef Hprd Interaction:
MAP2K4
—
MAPK14
(in vivo)
Lin et al., Science 1995*, Xia et al., Genes Dev 1998*
-
IRef Hprd Interaction:
MAP2K4
—
MAPK14
(in vitro)
Lin et al., Science 1995*, Xia et al., Genes Dev 1998*
-
IRef Innatedb Interaction:
MAP2K4
—
MAPK14
(unknown, -)
Ho et al., J Biol Chem 2003
-
IRef Ophid Interaction:
MAP2K4
—
MAPK14
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
STRING interaction:
MAPK14
—
MAP2K4
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAPK14
—
MAP2K4
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAPK14
—
MAP2K4
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAP2K4
—
MAPK14
(interaction, mapped from reactome)
-
STRING interaction:
MAP2K4
—
MAPK14
(interaction, mapped from reactome)
-
STRING interaction:
MAP2K4
—
MAPK14
(interaction, mapped from reactome)
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Fanning et al., J Biol Chem 2003
(MAP Kinase Signaling System...) :
Mechanical compression induced a phased phosphorylation of ERK consisting of a rapid induction of ERK1/2 phosphorylation at 10 min, a rapid decay, and a sustained level of ERK2 phosphorylation that persisted for at least 24 h. Mechanical compression also
induced the phosphorylation of p38
MAPK in strictly a transient fashion, with maximal phosphorylation occurring at 10 min. Mechanical compression stimulated
SEK1 phosphorylation, with a maximum at the relatively delayed time point of 1 h and with a higher amplitude than ERK1/2 and p38 MAPK phosphorylation
Lin et al., Science 1995
:
JNKK also
activated another
MAPK , p38 ( Mpk2 ; the mammalian homolog of HOG1 from yeast ), whose activity is regulated similarly to that of the JNKs
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Guan et al., J Biol Chem 1998
:
We also found that overexpression of the constitutively active form of
SEK1 ( SEK1-ED )
increases both p38
MAPK and JNK/SAPK phosphorylation, and increases PGE2 production and Cox-2 expression
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner
Ganiatsas et al., Proc Natl Acad Sci U S A 1998
:
SEK1 (
MKK4/JNKK ) is a
mitogen activated protein kinase activator that has been shown to participate in vitro in two stress activated cascades terminating with the SAPK and p38 kinases