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AKT1 — DAB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Jossin et al., Mol Cell Biol 2007
:
We show that the mTor ( mammalian target of rapamycin ) -S6K1 ( S6 kinase 1 ) pathway is activated by Reelin and that this depends on
Dab1 ( Disabled-1 ) phosphorylation and
activation of PI3K and
Akt ( protein kinase B )
Yang et al., Proc Natl Acad Sci U S A 2009
:
Thus, we propose that ligation of ApoER2 by APC signals via
Dab1 phosphorylation and subsequent
activation of PI3K and
Akt and inactivation of GSK3beta, thereby contributing to APC 's beneficial effects on cells