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AKT1 — NOS1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hisamoto et al., J Biol Chem 2001
:
Estrogen induces the
Akt dependent activation of endothelial
nitric-oxide synthase in vascular endothelial cells
Hisamoto et al., J Biol Chem 2001
:
Induction of endothelial
nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially
mediated by
Akt and extracellular signal regulated protein kinase in vascular endothelial cells
Hurt et al., Proc Natl Acad Sci U S A 2002
:
Akt dependent phosphorylation of endothelial
nitric-oxide synthase mediates penile erection
Haynes et al., J Biol Chem 2003
:
Src kinase mediates phosphatidylinositol
3-kinase/Akt dependent rapid endothelial
nitric-oxide synthase activation by estrogen
Park et al., J Immunol 2003
:
Akt as a mediator of secretory phospholipase A2 receptor
involved inducible
nitric oxide synthase expression
Barsacchi et al., Mol Pharmacol 2003
:
Activation of endothelial
nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway
involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3 ' kinase, and
Akt
Smith et al., Biochem Soc Trans 2003
:
Vascular endothelial dysfunction in aging : loss of
Akt dependent endothelial
nitric oxide synthase phosphorylation and partial restoration by ( R ) -alpha-lipoic acid
Kang et al., J Pharmacol Exp Ther 2004
(Cystitis...) :
Activated
Akt phosphorylates human eNOS at serine 1177 and subsequently
increases NOS activity
Iaccarino et al., Circulation 2004
(Hypertension) :
It was recently reported that
AKT phosphorylates and
activates endothelial
nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction
Florian et al., Steroids 2004
:
Estrogen induced changes in
Akt dependent activation of endothelial
nitric oxide synthase and vasodilation
Philipp et al., Am J Physiol Heart Circ Physiol 2006
:
NOS is
activated by
Akt
Sun et al., Toxicol Appl Pharmacol 2006
:
Serine 1179 phosphorylation of endothelial
nitric oxide synthase caused by 2,4,6-trinitrotoluene through
PI3K/Akt signaling in endothelial cells
Penna et al., J Cardiovasc Med (Hagerstown) 2006
:
They also produce a transient dilator effect via the activation of endothelial
nitric oxide synthase mediated by protein kinase
B/Akt
Nakata et al., Arterioscler Thromb Vasc Biol 2007
:
Inhibition of
Akt by dominant negative Akt
suppressed atorvastatin induced
nNOS expression as well as Akt and NF-kappaB activation
Zecchin et al., Diabetes 2007
(Obesity) :
In addition, ACh induces JAK2/IRS-1 and IRS-1/phosphatidylinositol (PI) 3-kinase associations, downstream
activation of
Akt/protein kinase B, endothelial
cell-nitric oxide synthase ( eNOS ), and extracellular signal regulated kinase ( ERK ) -1/2
Blanes et al., J Biol Chem 2007
:
Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for
Akt dependent endothelial
nitric-oxide synthase activation and nitric oxide release from endothelial cells
Grossini et al., Endocrinology 2008
:
In porcine aortic endothelial cells, genistein
induced the phosphorylation of endothelial
nitric oxide synthase and NO production through ERK 1/2,
Akt , and p38 MAPK pathways, which was prevented by the concomitant treatment by butoxamine and fulvestrant
Drouin et al., Stroke 2009
:
In healthy C57Bl/6 mouse cerebral arteries,
Akt dependent activation of endothelial
nitric oxide synthase derived H ( 2 ) O ( 2 ) mediates flow dependent dilation
Llansola et al., Neurochem Int 2010
:
This is due to reduced NMDA induced increase in cAMP, reduced
activation of Akt by cAMP and of
nNOS by
Akt
Csibi et al., PloS one 2010
:
Inhibition of
nitric oxide synthase and NAD ( P ) Hoxidase and scavenging of free radicals with myricetin
restored insulin stimulated
Akt phosphorylation and GLUT4 translocation in the presence of Ang II
Chen et al., Life Sci 2010
:
Calcium- and phosphatidylinositol
3-kinase/Akt dependent activation of endothelial
nitric oxide synthase by apigenin
Pellegrin et al., Can J Physiol Pharmacol 2011
:
Long-term swimming exercise does not modulate the
Akt dependent endothelial
nitric oxide synthase phosphorylation in healthy mice
Conrad et al., Semin Nephrol 2011
(Pre-Eclampsia) :
Newly emerging data support the role of Ga ( i/o ) protein coupling to phosphatidylinositol-3
kinase/Akt ( protein kinase B ) -dependent phosphorylation and
activation of endothelial
nitric oxide synthase in the rapid vasodilatory responses of relaxin
Ferreira et al., J Neurosci 2011
:
These results suggest that
NMDAR/Akt dependent
nNOS phosphorylation is coupled to GLUT3 trafficking
Wu et al., Neurosurgery 2011
(Brain Injuries) :
Akt dependent endothelial
nitric oxide synthase phosphorylation was also induced by simvastatin in vivo and in vitro
Li et al., J Vasc Surg 2012
(Carotid Stenosis...) :
Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing phosphatidylinositol
3-kinase/Akt dependent heat-shock protein/endothelial
nitric oxide synthase signaling
Hong et al., J Agric Food Chem 2012
(Hypertension) :
Panax ginseng extract rich in ginsenoside protopanaxatriol attenuates blood pressure elevation in spontaneously hypertensive rats by affecting the
Akt dependent phosphorylation of endothelial
nitric oxide synthase
Pasarín et al., PloS one 2012
(Fatty Liver...) :
This was associated with a decreased
Akt dependent eNOS phosphorylation and
NOS activity
Song et al., Int J Mol Med 2012
:
The phosphorylation levels of
nNOS at Ser1412,
induced by activation of
Akt/PKB or CaM-K II, but not by PKA signaling, were reduced by pre-treatment with the NO donor diethylamine-NONOate ... The phosphorylation levels of
nNOS at Ser1412,
induced by activation of
Akt/PKB or CaM-K II, but not by PKA signaling, were reduced by pre-treatment with the NO donor diethylamine-NONOate ... Furthermore, the levels of phosphorylation of
nNOS at Ser1412,
induced by
Akt/PKB or CaM-K II but not by PKA signaling, were enhanced by inhibition of nNOS activity with 7-nitroindazole
Rafikov et al., J Biol Chem 2013
:
Asymmetric dimethylarginine
induces endothelial
nitric-oxide synthase mitochondrial redistribution through the nitration mediated activation of
Akt1
Jaba et al., J Clin Invest 2013
:
NOS inhibitor L-NAME also significantly attenuated RGS4 degradation, and
reduced activation of
AKT/mTORC1 signaling and induction of myocardial hypertrophy in PlGF transgenic mice, while conditional cardiac-specific PlGF expression in eNOS knockout mice did not induce myocardial hypertrophy
Bolduc et al., Am J Physiol Heart Circ Physiol 2013
:
First, exercise increases blood flow locally and increases shear stress temporarily, a known stimulus for endothelial cell maintenance of
Akt dependent expression of endothelial
nitric oxide synthase , nitric oxide generation, and the expression of antioxidant defenses