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AKT1 — PTK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Kue et al., J Urol 2000
(Prostatic Neoplasms) :
Whereas activation of
Akt by these stimuli is not
dependent on
protein tyrosine kinase activation, it is mediated by PI3K
Hauck et al., EMBO J 2002
(Lung Neoplasms) :
However,
FRNK did not
affect v-Src stimulated
Akt activation, cell growth in soft agar, or subcutaneous tumor formation in nude mice
Sengupta et al., Arterioscler Thromb Vasc Biol 2003
(MAP Kinase Signaling System...) :
PTK787 inhibited the VEGF induced activation of
Akt and ERKs, without affecting the HGF/SF induced phosphorylation
van Nimwegen et al., Mol Pharmacol 2006
(Mammary Neoplasms, Experimental) :
FRNK inhibited the doxorubicin induced activation of
PKB
Mehdi et al., Biochemistry 2006
:
Since BMOV is an inhibitor of protein tyrosine phosphatases and through enhanced tyrosine phosphorylation may activate various protein tyrosine kinases ( PTK ), we have investigated the potential
role of different receptor or nonreceptor
PTK in mediating BMOV induced
PKB phosphorylation
Wei et al., Am J Physiol Heart Circ Physiol 2008
(Myocardial Reperfusion Injury) :
Increased expression of a FAK inhibitor,
FRNK ,
reduced AKT phosphorylation in response to HS both at time 0 and after 10 min of CI compared with myocytes expressing empty virus
Liu et al., Lab Invest 2009
(Disease Models, Animal...) :
PTK/ZK also induced cell cycle arrest, accompanied by increasing the expression of p27 ( Kip1 ) and downregulation of cyclin D1 and cyclin E. PTK/ZK significantly
inhibited vascular endothelial growth factor ( VEGF ) expression, as well as VEGF simulated cell proliferation and phosphorylation of
Akt in activated HSCs
Liu et al., Lab Invest 2009
(Liver Cirrhosis) :
We provide evidence that
PTK787/ZK222584 ( PTK/ZK ) , a potent tyrosine kinase inhibitor that blocks vascular endothelial growth factor receptor ( VEGFR ), significantly
inhibits PDGF receptor expression, as well as PDGF simulated HSC proliferation, migration and phosphorylation of ERK1/2,
Akt and p70S6 kinase
Zheng et al., Mol Cell Biol 2010
:
Our data indicate that in addition to promoting growth factor receptor mediated activation of AKT,
PTK6 can directly
activate AKT to promote oncogenic signaling
Weidenaar et al., Mol Cancer Res 2013
(Leukemia, Myeloid, Acute...) :
Proteome profiler array analysis of downstream kinases revealed that
PTK/ZK reduced activation of
PI3K/Akt kinase signaling