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AKT1 — SNX1
Text-mined interactions from Literome
Okawa et al., Blood 2009
(Leukemia...) :
SNX-2112 inhibits cytokine induced
Akt and extracellular signal related kinase ( ERK ) activation and also overcomes the growth advantages conferred by interleukin-6, insulin-like growth factor-1, and bone marrow stromal cells
Bachleitner-Hofmann et al., Clin Cancer Res 2011
:
In all cell lines,
SNX-2112 led to degradation of MET, HER-2, EGFR, and
AKT , as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest