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CXCR4 — TNF

Text-mined interactions from Literome

Shirazi et al., J Hum Virol 1998 : Although treatment of PBMCs with interferon-alpha ( IFN-alpha ) and IFN-gamma led to a significant repression of CXCR4 gene expression, interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) had no significant effect on CXCR4 gene expression in PBMCs. IFN-alpha and IFN-gamma also inhibited CXCR4 gene expression in the promyelocytic cell line U937, and this inhibition led to a decrease in cell-cell fusion between U937 cells and HeLa-MAGI cells ... In U937 cells, TNF-alpha and phorbol myristate acetate ( PMA ) stimulated CXCR4 gene transcription ; this effect was reversed with prior treatment of cells with IFN-gamma
Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5, CCR-6, and CXCR-4 , and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Nagase et al., J Immunol 2000 : The surface expression of CXCR4 in eosinophils was up-regulated by IFN-gamma, TNF-alpha , and TGF-beta while it was down-regulated by IL-4 and eosinophil directed hemopoietins such as IL-5
Brice et al., J Acquir Immune Defic Syndr 2000 : However, while TNF-alpha has a protective role in antiviral resistance of activated CD4+ T cells to R5-tropic viruses, it enhances CXCR4 expression of CD4+ T cells and mediates increased susceptibility to infection with X4-tropic strains of HIV and recombinant SIVs
Oh et al., J Immunol 2001 (Astrocytoma...) : The peak of CXCR4 expression in response to TNF-alpha and IL-1beta was 8 and 4 h, respectively
Croitoru-Lamoury et al., Glia 2003 : Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation
Küry et al., Mol Cell Neurosci 2003 : Cyclic AMP and tumor necrosis factor-alpha regulate CXCR4 gene expression in Schwann cells
Kulbe et al., Cancer Res 2005 (Ovarian Neoplasms) : TNF-alpha stimulation activated components of the nuclear factor kappaB pathway, and overexpression of the inhibitor of kappaB also reduced CXCR4 expression
Schutyser et al., Eur Cytokine Netw 2007 (Anoxia...) : Our semi-quantitative RT-PCR analysis demonstrated that TNF-alpha and IFN-gamma repressed CXCR4 mRNA levels in immortalized human microvascular endothelial HMEC-1 cells after 4 h, whereas only TNF-alpha displayed inhibitory activity in primary human microvascular endothelial cells ( HMVEC )
Kim et al., Leukemia & lymphoma 2009 (Anoxia...) : Tumor necrosis factor-alpha (TNF-alpha) , transforming growth factor-beta1 ( TGF-beta1 ), and vascular endothelial growth factor ( VEGF ) enhanced CXCR4 expression in RPMI8226 cells
Egea et al., Cell Death Differ 2011 (Brain Neoplasms...) : In addition, TNF-a significantly enhanced expression of the chemokine receptor CXCR4 ( CXC motive chemokine receptor 4 ), which facilitated the chemotactic invasiveness of hMSCs toward stromal cell derived factor 1 (SDF-1) alpha
Asagoe et al., J Immunol 1998 : In contrast, CXCR1 expression was not affected by TNF-alpha