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BMP4 — TNF
Text-mined interactions from Literome
Horiguchi et al., Cytokine 2000
:
These results indicate that
TNF-alpha stimulates both cell proliferation and
BMP-4 expression but inhibits chondrogenesis in chondroprogenitor-like ATDC5 cells
Kaneki et al., J Biol Chem 2006
:
TNF inhibited the expression of
bone morphogenetic protein and transforming growth factor-beta signaling reporter constructs, and the inhibition of each was blocked by Smurf1 siRNA and Smurf2 siRNA, respectively
He et al., Zhonghua Wai Ke Za Zhi 2006
:
To study the feasibility of osteogenic phenotype expression by human skin fibroblasts induced in polyglycolic acid ( PGA ) foams and the
effect of
tumor necrosis factor-alpha (TNF-alpha) on the expression of
bone morphogenetic protein ( BMP ) receptors
Singhatanadgit et al., Int J Biochem Cell Biol 2006
:
Bone morphogenetic protein receptors and
bone morphogenetic protein signaling are
controlled by
tumor necrosis factor-alpha in human bone cells
Zhu et al., Gene 2007
:
TNF-alpha represses transcription of human
Bone Morphogenetic Protein-4 in lung epithelial cells ... In this study we examined whether
TNF-alpha , which activates NF-kB, can
regulate Bmp4 gene expression ...
TNF-alpha reduced Bmp4 mRNA in lung adenocarcinoma A549 cells and
repressed transcriptional activity of the human
Bmp4 promoter in a dose dependent manner ... In support of this finding, the repressor
effect of
TNF-alpha on
Bmp4 was abrogated by a co-transfected dominant negative mutant of IkB ( S32A/S36A )
Hong et al., Immunology 2009
:
In addition,
BMP-6 induced expression of pro-inflammatory inducible nitric oxide synthase (iNOS) and the cytokine tumour necrosis factor
(TNF)-alpha
Yamazaki et al., J Biol Chem 2009
:
These results suggest that
TNFalpha inhibits
BMP signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB
Xu et al., FASEB J 2011
(Choroidal Neovascularization...) :
Transcriptional
regulation of
bone morphogenetic protein 4 by
tumor necrosis factor and its relationship with age related macular degeneration
Pacios et al., FASEB J 2012
(Diabetes Mellitus, Experimental...) :
TNF inhibition in diabetic animals also reduced apoptosis, increased proliferation of bone lining cells, and
increased mRNA levels of FGF-2, TGFß-1,
BMP-2 , and BMP-6
Nakase et al., Bone 1997
:
The modulatory
effects of interleukin (IL)-1 beta and
tumor necrosis factor (TNF)-alpha on bone morphogenetic protein
(BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells